CLINICAL AND IMMUNOLOGICAL EFFICACY OF ASPIRIN DESENSITIZATION IN NASAL POLYP PATIENTS WITH ASPIRIN- EXACERBATED RESPIRATORY DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MORTAZAVI NEGAR; ESMAEILZADEH HOSSEIN; ABBASINAZARI MOHAMMAD; BABAIE DELARA; ALYASIN SOHEILA; NABAVIZADEH HESAMODIN; ESMAILZADEH ELMIRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1639-1647

Download Full-Text

View:

216

Download:

149

Cites:

Information Journal Paper

Title

CLINICAL AND IMMUNOLOGICAL EFFICACY OF ASPIRIN DESENSITIZATION IN NASAL POLYP PATIENTS WITH ASPIRIN- EXACERBATED RESPIRATORY DISEASE

Author(s)

Keywords

AERD

ASPIRIN

DESENSITIZATION

INTERLEUKIN-5

INTERLEUKIN-4

Abstract

This study aimed to investigate the efficacy and the underlining mechanism of ASPIRIN DESENSITIZATION among patients with ASPIRIN Exacerbated Respiratory Disease (AERD). Thirty- eight patients, who had undergone an ASPIRIN challenge test and were diagnosed as having AERD, were engaged in a double- blind randomized clinical trial. They were divided into two groups- an active group of patients who went through ASPIRIN DESENSITIZATION, and the control group, receiving placebo. Clinical symptoms and the quality of life of the patients- in addition to the levels of interleukin 4 and 5 (IL4), (IL5)-were documented at the beginning of the study and again after six months of ASPIRIN DESENSITIZATION. The quality of life of the patients was significantly higher in the active group after six months (P=0.001). Medication requirements and symptom score were manifested to be significantly lower in the active group after six months than at the beginning of the study (P=0.005, 0.017 respectively). Forced expiratory volume in the second one (FEV1) was, also, significantly higher in the active group after six months of the study (P=0.032). IL5 was found to be significantly lower in the active group after six months (P=0.019). However, no significant difference was observed in the levels of IL4 between the two groups (P=0.152). The study revealed that ASPIRIN DESENSITIZATION can improve the quality of life of patients with AERD, lessen their symptoms and medication requirements, lower their levels of IL5, and improve some pulmonary function tests such as FEV1.

Cites

No record.

References

No record.

Cite

APA: Copy

MORTAZAVI, NEGAR, ESMAEILZADEH, HOSSEIN, ABBASINAZARI, MOHAMMAD, BABAIE, DELARA, ALYASIN, SOHEILA, NABAVIZADEH, HESAMODIN, & ESMAILZADEH, ELMIRA. (2017). CLINICAL AND IMMUNOLOGICAL EFFICACY OF ASPIRIN DESENSITIZATION IN NASAL POLYP PATIENTS WITH ASPIRIN- EXACERBATED RESPIRATORY DISEASE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1639-1647. SID. https://sid.ir/paper/288727/en

Vancouver: Copy

MORTAZAVI NEGAR, ESMAEILZADEH HOSSEIN, ABBASINAZARI MOHAMMAD, BABAIE DELARA, ALYASIN SOHEILA, NABAVIZADEH HESAMODIN, ESMAILZADEH ELMIRA. CLINICAL AND IMMUNOLOGICAL EFFICACY OF ASPIRIN DESENSITIZATION IN NASAL POLYP PATIENTS WITH ASPIRIN- EXACERBATED RESPIRATORY DISEASE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1639-1647. Available from: https://sid.ir/paper/288727/en

IEEE: Copy

NEGAR MORTAZAVI, HOSSEIN ESMAEILZADEH, MOHAMMAD ABBASINAZARI, DELARA BABAIE, SOHEILA ALYASIN, HESAMODIN NABAVIZADEH, and ELMIRA ESMAILZADEH, “CLINICAL AND IMMUNOLOGICAL EFFICACY OF ASPIRIN DESENSITIZATION IN NASAL POLYP PATIENTS WITH ASPIRIN- EXACERBATED RESPIRATORY DISEASE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1639–1647, 2017, [Online]. Available: https://sid.ir/paper/288727/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops