مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

EXPOSURE TO ANTINEOPLASTIC AGENTS INDUCES CYTOTOXICITY IN NURSE LYMPHOCYTES: ROLE OF MITOCHONDRIAL DAMAGE AND OXIDATIVE STRESS

Pages

  43-52

Abstract

 Cytotoxicity and mitochondrial parameters were studied in isolated lymphocytes and their mitochondria obtained from occupationally exposed NURSES through INHALATION EXPOSURE to ANTINEOPLASTIC DRUGS and results were compared to those of unexposed NURSES. The group of occupationally exposed NURSES consisted of 50 individuals ranging in age from 30 to 35 years. The control group included 50 NURSES who were not occupationally exposed to the preparation and handling of ANTINEOPLASTIC DRUGS and their anthropometric and biochemical characteristics were similar to those of the expose group. All cytotoxicity and mitochondrial parameters evaluated in exposed group were significantly increased (P<0.05) compared to the unexposed control group. Finally, the results of our study suggest that using antioxidant, mitochondrial and lysosomal protective agents can be promising drug candidates for the hospital staff in the risk of exposure to exposure to ANTINEOPLASTIC DRUGS.

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    APA: Copy

    EGHBAL, MOHAMMAD ALI, YUSEFI, ELHAM, TAVAKOLI ARDAKANI, MARIA, RAMAZANI, MARAL, Zarei, Mohammad Hadi, SALIMI, AHMAD, & POURAHMAD, JALAL. (2018). EXPOSURE TO ANTINEOPLASTIC AGENTS INDUCES CYTOTOXICITY IN NURSE LYMPHOCYTES: ROLE OF MITOCHONDRIAL DAMAGE AND OXIDATIVE STRESS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(SUPPLEMENT), 43-52. SID. https://sid.ir/paper/288783/en

    Vancouver: Copy

    EGHBAL MOHAMMAD ALI, YUSEFI ELHAM, TAVAKOLI ARDAKANI MARIA, RAMAZANI MARAL, Zarei Mohammad Hadi, SALIMI AHMAD, POURAHMAD JALAL. EXPOSURE TO ANTINEOPLASTIC AGENTS INDUCES CYTOTOXICITY IN NURSE LYMPHOCYTES: ROLE OF MITOCHONDRIAL DAMAGE AND OXIDATIVE STRESS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(SUPPLEMENT):43-52. Available from: https://sid.ir/paper/288783/en

    IEEE: Copy

    MOHAMMAD ALI EGHBAL, ELHAM YUSEFI, MARIA TAVAKOLI ARDAKANI, MARAL RAMAZANI, Mohammad Hadi Zarei, AHMAD SALIMI, and JALAL POURAHMAD, “EXPOSURE TO ANTINEOPLASTIC AGENTS INDUCES CYTOTOXICITY IN NURSE LYMPHOCYTES: ROLE OF MITOCHONDRIAL DAMAGE AND OXIDATIVE STRESS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. SUPPLEMENT, pp. 43–52, 2018, [Online]. Available: https://sid.ir/paper/288783/en

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