PARTIAL LEAST SQUARE AND PARALLEL FACTOR ANALYSIS METHODS APPLIED FOR SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Amraei Ahmadreza; NIAZI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:4 Page(s): 1191-1200

Download Full-Text

View:

187

Download:

278

Cites:

Information Journal Paper

Title

PARTIAL LEAST SQUARE AND PARALLEL FACTOR ANALYSIS METHODS APPLIED FOR SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS

Author(s)

Amraei Ahmadreza | NIAZI ALI | Issue Writer Certificate

Keywords

CEFIXIME

PARAFAC

PHARMACEUTICAL PREPARATIONS

URINE

PLASMA

DATAN

ACID DISSOCIATION CONSTANT

Abstract

In this study, the direct determination of CEFIXIME as an anti-bacterial agent, in pharmaceutical formulations, URINE and human blood PLASMA was conducted based on spectrophotometric measurements using parallel factor analysis (PARAFAC) and partial least squares (PLS). The calibration set was composed of fourteen solutions in the range of 0.50- 9.00 mg mL-1. PLS models were calculated at each pH applied to determine a set of synthetic CEFIXIME solutions. The best model was acquired at pH 1.02 (PLS-pH 1.02). The ability of the method for the analysis of real samples was considered by determination of CEFIXIME in PHARMACEUTICAL PREPARATIONS, URINE and PLASMA with satisfactory results. The calculated model with PARAFAC showed good prediction capability with root mean square error of prediction (RMSEP) of 0.12 for CEFIXIME. The ACID DISSOCIATION CONSTANTs (pKa) of CEFIXIME play a fundamental role in the mechanism of activity of CEFIXIME. The pKa of CEFIXIME were estimated by DATAN program using the corresponding absorption spectra-pH data. The calculated pKa values of CEFIXIME were 1.89 and 3.80 for pKa1 and pKa2 respectively.

Cites

No record.

References

No record.

Cite

APA: Copy

Amraei, Ahmadreza, & NIAZI, ALI. (2018). PARTIAL LEAST SQUARE AND PARALLEL FACTOR ANALYSIS METHODS APPLIED FOR SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1191-1200. SID. https://sid.ir/paper/288880/en

Vancouver: Copy

Amraei Ahmadreza, NIAZI ALI. PARTIAL LEAST SQUARE AND PARALLEL FACTOR ANALYSIS METHODS APPLIED FOR SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1191-1200. Available from: https://sid.ir/paper/288880/en

IEEE: Copy

Ahmadreza Amraei, and ALI NIAZI, “PARTIAL LEAST SQUARE AND PARALLEL FACTOR ANALYSIS METHODS APPLIED FOR SPECTROPHOTOMETRIC DETERMINATION OF CEFIXIME IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1191–1200, 2018, [Online]. Available: https://sid.ir/paper/288880/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops