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Information Journal Paper

Title

INFLUENCE OF DOTA CHELATORS ON RADIOCHEMICAL PURITY AND BIODISTRIBUTION OF 177LU- AND 90Y-RITUXIMAB IN XENOGRAFTED MICE

Pages

  1201-1208

Abstract

 This work presents a comparative biological evaluation of 90Y- and 177Lu- labelled DOTA-SCN and DOTA-NHS conjugated to RITUXIMAB in tumour-bearing mice. Two DOTA derivatives, p-SCN-Bn-DOTA and DOTA-NHS-ester were conjugated to RITUXIMAB and then freeze-dried kit formulations were prepared, as previously described (1). Tissue distribution was investigated in tumour-bearing (Raji s.c.) male Rj: NMRI-Foxn1nu/Foxn1nu mice at different time points after administration of 177Lu-DOTA-Rituximab or 90Y-DOTA-Rituximab (6 MBq/10 mg per mouse). In addition, tumour images were acquired with a PhotonIMAGERTM after injection of 90Y-DOTA (SCN) -Rituximab. All radioimmunoconjugates were obtained with high radiolabelling yield (RCP>98%) and specific activity of ca.0.6 GBq/mg. The conjugates were stable in human serum and in 0.9% NaCl; however, progressive aggregation was observed with time, in particular for DOTA- (SCN) conjugates. Both 177Lu- and 90Y-DOTA - (SCN) -Rituximab revealed slow blood clearance. The maximum tumour uptake was found 72 h after injection of 177Lu-DOTA- (SCN) -Rituximab (9.3 ID/g). A high radioactivity uptake was observed in liver and spleen, confirming the hepatobiliary excretion route. The results obtained by the radioactive optical imaging harmonize with those from the biodistribution study.

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    APA: Copy

    KARCZMARCZYK, URSZULA, WOJDOWSKA, WIOLETTA, MAURIN, MICHA?, LASZUK, EWA, & GARNUSZEK, PIOTR. (2018). INFLUENCE OF DOTA CHELATORS ON RADIOCHEMICAL PURITY AND BIODISTRIBUTION OF 177LU- AND 90Y-RITUXIMAB IN XENOGRAFTED MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1201-1208. SID. https://sid.ir/paper/288888/en

    Vancouver: Copy

    KARCZMARCZYK URSZULA, WOJDOWSKA WIOLETTA, MAURIN MICHA?, LASZUK EWA, GARNUSZEK PIOTR. INFLUENCE OF DOTA CHELATORS ON RADIOCHEMICAL PURITY AND BIODISTRIBUTION OF 177LU- AND 90Y-RITUXIMAB IN XENOGRAFTED MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1201-1208. Available from: https://sid.ir/paper/288888/en

    IEEE: Copy

    URSZULA KARCZMARCZYK, WIOLETTA WOJDOWSKA, MICHA? MAURIN, EWA LASZUK, and PIOTR GARNUSZEK, “INFLUENCE OF DOTA CHELATORS ON RADIOCHEMICAL PURITY AND BIODISTRIBUTION OF 177LU- AND 90Y-RITUXIMAB IN XENOGRAFTED MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1201–1208, 2018, [Online]. Available: https://sid.ir/paper/288888/en

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