مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

213
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

195
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

APPLICATION OF A NANOPOROUS METAL ORGANIC FRAMEWORK BASED ON IRON CARBOXYLATE AS DRUG DELIVERY SYSTEM

Pages

  1164-1171

Abstract

 In the present study, a nanoporous METAL ORGANIC FRAMEWORK (MOF) based on iron metal and amino terephthalate ligand MIL-101-NH2-Fe has been used as a carrier for loading and in-vitro release of 5-FLUROURACIL (5-FU) anticancer drug. The 5-FU drug loaded MOF was 13 wt % by using thermogravimetric analysis (TGA). The 5-FU release was monitored under physiological condition at 37oC, pH 7.4 in simulated body fluid (SBF) by using spectrophotometry. The drug demonstrated a slow release profile where 98% of the drug was released in 4 days. Loading of drug was characterized by Fournier transform infrared (FTI-IR) and thermogravimetric analysis (TGA). The crystalline structure was monitored by using X-ray powder diffraction (XRD) and after loading of drug in the MOF, the pattern of samples was remained the same. The morphology and size of samples were showed by using scanning electron microscopy (SEM) and based on the MOF has a length of 500 nm and an average diameter of 200 nm. These structural characterizations were performed to verify the 5-FU drug loading in MIL-101-NH2- Fe. The MOF stability was studied by measuring the iron concentration in the SBF solution with atomic absorption spectroscopy (AAS). The MTT assay method was assessed the ability of this DRUG DELIVERY SYSTEM on overcoming MCF-7 breast cancer cells in comparison with the free drug and the carrier alone. Based on the results, this drug loaded nanoparticle could achieve more cell death as compared to the free 5-FU drug.

Cites

References

  • No record.

    • Cite

    APA: Copy

    MIRI, BAHARE, MOTAKEF KAZEMI, NEGAR, SHOJAOSADATI, SEYED ABBAS, & MORSALI, ALI. (2018). APPLICATION OF A NANOPOROUS METAL ORGANIC FRAMEWORK BASED ON IRON CARBOXYLATE AS DRUG DELIVERY SYSTEM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1164-1171. SID. https://sid.ir/paper/288902/en

    Vancouver: Copy

    MIRI BAHARE, MOTAKEF KAZEMI NEGAR, SHOJAOSADATI SEYED ABBAS, MORSALI ALI. APPLICATION OF A NANOPOROUS METAL ORGANIC FRAMEWORK BASED ON IRON CARBOXYLATE AS DRUG DELIVERY SYSTEM. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1164-1171. Available from: https://sid.ir/paper/288902/en

    IEEE: Copy

    BAHARE MIRI, NEGAR MOTAKEF KAZEMI, SEYED ABBAS SHOJAOSADATI, and ALI MORSALI, “APPLICATION OF A NANOPOROUS METAL ORGANIC FRAMEWORK BASED ON IRON CARBOXYLATE AS DRUG DELIVERY SYSTEM,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1164–1171, 2018, [Online]. Available: https://sid.ir/paper/288902/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button