FIRST TRANSCRIPTOME ANALYSIS OF IRANIAN SCORPION, MESOBUTHUS EUPEUS VENOM GLAND

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BARADARAN MASOUMEH; JALALI AMIR; NADERI SOORKI MARYAM; Jokar Mahmoud; GALEHDARI HAMID

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:4 Page(s): 1488-1502

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Title

FIRST TRANSCRIPTOME ANALYSIS OF IRANIAN SCORPION, MESOBUTHUS EUPEUS VENOM GLAND

Author(s)

Keywords

CDNA LIBRARY

MESOBUTHUS EUPEUS

TRANSCRIPTOME ANALYSIS

CHLOROTOXIN-LIKE PEPTIDE

HOMOLOGY MODELING

MOLECULAR DYNAMICS FLEXIBLE FITTING (MDFF)

Abstract

Scorpions are generally an important source of bioactive components, including toxins and other small peptides as attractive molecules for new drug development. MESOBUTHUS EUPEUS, from medically important and widely distributed Buthidae family, is the most abundant species in Iran. Researchers are interesting on the gland of this scorpion due to the complexity of its venom. Here, we have analyzed the transcriptome based on expressed sequence tag (EST) database from the venom tissue of Iranian M. eupeus by constructing a CDNA LIBRARY and subsequent Sanger sequencing of obtained inserts. Sixty-three unique transcripts were identified, which were grouped in different categories, including Toxins (44 transcripts), Cell Proteins (9 transcripts), Antimicrobial Peptides (4 transcripts) and Unknown Peptides (3 transcripts). The analysis of the ESTs revealed several new components categorized among various toxin families with effect on ion channels. Sequence analysis of a new precursor provides evidence to validate the first CaTxs from M. eupeus. The results are exploration of the diversity of precursors expressed of Iranian M. eupeus venom gland. We further described comparative analysis of venom components of Iranian M. eupeus with other sibling species.

Cites

Evaluation of the interference effect of cyclosporine and Mesobut scorpion venom on some biochemical and histological parameters in parenchymal tissue of liver and kidney of male mice

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APA: Copy

BARADARAN, MASOUMEH, JALALI, AMIR, NADERI SOORKI, MARYAM, Jokar, Mahmoud, & GALEHDARI, HAMID. (2018). FIRST TRANSCRIPTOME ANALYSIS OF IRANIAN SCORPION, MESOBUTHUS EUPEUS VENOM GLAND. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1488-1502. SID. https://sid.ir/paper/288905/en

Vancouver: Copy

BARADARAN MASOUMEH, JALALI AMIR, NADERI SOORKI MARYAM, Jokar Mahmoud, GALEHDARI HAMID. FIRST TRANSCRIPTOME ANALYSIS OF IRANIAN SCORPION, MESOBUTHUS EUPEUS VENOM GLAND. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1488-1502. Available from: https://sid.ir/paper/288905/en

IEEE: Copy

MASOUMEH BARADARAN, AMIR JALALI, MARYAM NADERI SOORKI, Mahmoud Jokar, and HAMID GALEHDARI, “FIRST TRANSCRIPTOME ANALYSIS OF IRANIAN SCORPION, MESOBUTHUS EUPEUS VENOM GLAND,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1488–1502, 2018, [Online]. Available: https://sid.ir/paper/288905/en

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