EVALUATION OF NOVEL α-(ACYLOXY)-α-(QUINOLIN-4-YL) ACETAMIDES AS ANTIPLASMODIAL AGENTS

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RAMAZANI ALI; KHOSRAVANI BEHNAM; TARAN JAFAR; RAMAZANI ALI

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:3 Page(s): 924-928

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Title

EVALUATION OF NOVEL α-(ACYLOXY)-α-(QUINOLIN-4-YL) ACETAMIDES AS ANTIPLASMODIAL AGENTS

Author(s)

RAMAZANI ALI | KHOSRAVANI BEHNAM | TARAN JAFAR | RAMAZANI ALI | Issue Writer Certificate

Keywords

PLASMODIUM FALCIPARUM

QUINOLINES

CYTOTOXICITY

HEPG2

3D7 STRAIN

Abstract

Because of expanding resistance to efficient and affordable antimalarial drugs like chloroquine, the search is continuing for more effective drugs against this disease. In-vitro antiplasmodial activity and CYTOTOXICITY of a- (acyloxy) -a- (quinolin-4-yl) acetamides on PLASMODIUM FALCIPARUM and structure-activity relationships of this new class of Passerini adducts is described. The in-vitro antiplasmodial activity of compounds was tested against chloroquine sensitive 3D7 STRAIN. Toxicity of active compounds was investigated on HEPG2 cell line. Compounds 1, 20 and 22 showed significant antiplasmodial activity with IC50 value of 1.511, 1.373 and 1.325 μM, respectively. The active compounds did not show noticeable toxicity when tested against HEPG2 cell line. The present results bring essential elements which will be used for the synthesis of more active derivatives of a- (acyloxy) -a - (quinolin-4-yl) acetamides.

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APA: Copy

RAMAZANI, ALI, KHOSRAVANI, BEHNAM, TARAN, JAFAR, & RAMAZANI, ALI. (2017). EVALUATION OF NOVEL α-(ACYLOXY)-α-(QUINOLIN-4-YL) ACETAMIDES AS ANTIPLASMODIAL AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(3), 924-928. SID. https://sid.ir/paper/289008/en

Vancouver: Copy

RAMAZANI ALI, KHOSRAVANI BEHNAM, TARAN JAFAR, RAMAZANI ALI. EVALUATION OF NOVEL α-(ACYLOXY)-α-(QUINOLIN-4-YL) ACETAMIDES AS ANTIPLASMODIAL AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(3):924-928. Available from: https://sid.ir/paper/289008/en

IEEE: Copy

ALI RAMAZANI, BEHNAM KHOSRAVANI, JAFAR TARAN, and ALI RAMAZANI, “EVALUATION OF NOVEL α-(ACYLOXY)-α-(QUINOLIN-4-YL) ACETAMIDES AS ANTIPLASMODIAL AGENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 3, pp. 924–928, 2017, [Online]. Available: https://sid.ir/paper/289008/en

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