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Information Journal Paper

Title

Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion

Pages

  687-693

Abstract

 This work aimed to prepare a nanoemulsion preparation containing budesonide and assess its aerodynamic behavior in comparison with suspension of budesonide. In-vitro aerodynamic performance of the corresponding micellar solution (ie. nanoemulsion preparation without oil) was investigated too. Nanoemulsions of almond oil containing budesonide, as a hydrophobic model drug molecule, were prepared and optimized. Then, the effect of variation of surfactant/ co-surfactant concentration on the aerodynamic properties of the nebulized aerosol was studied. The results indicated that the most physically stable formulation makes the smallest aerodynamic size. The concentration of co-surfactant was also shown to be critical in determination of aerodynamic size. Furthermore, the optimized sample, with 3% w/w almond oil, 20% w/w Tween 80+Span 80 and 2% w/w ethanol showed a smaller MMAD in comparison with the commercially available suspension and the micellar solution.

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    APA: Copy

    Kamali, Hosein, Abbasi, Shayan, Amini, Mohammad Ali, & AMANI, AMIR. (2016). Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(4), 687-693. SID. https://sid.ir/paper/289066/en

    Vancouver: Copy

    Kamali Hosein, Abbasi Shayan, Amini Mohammad Ali, AMANI AMIR. Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(4):687-693. Available from: https://sid.ir/paper/289066/en

    IEEE: Copy

    Hosein Kamali, Shayan Abbasi, Mohammad Ali Amini, and AMIR AMANI, “Investigation of Factors Affecting Aerodynamic Performance of Nebulized Nanoemulsion,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 4, pp. 687–693, 2016, [Online]. Available: https://sid.ir/paper/289066/en

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