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Information Journal Paper

Title

Natural Alpha-Glucosidase Inhibitors Rapid Fishing from Cyperus Rotundus Using Immobilized Enzyme Affinity Screening Combined with UHPLC-QTOF MS

Pages

  1508-1515

Abstract

 An efficient and rapid affinity-based screening method for directly fishing out natural Alpha-glucosidase inhibitors from Cyperus rotundus extract by using Immobilized enzyme technology combined with UHPLC-QTOF MS analysis was established. As a result without time-consuming and laborious isolation workload and false positive interference, five natural Alpha-glucosidase inhibitors were successfully recognized and identified from only 400 uL of C. rotundus extracts within only a couple of hours, which suggested that the screening method was rapid, economical, sensitive and feasible. In addition, the captured compounds were isolated and characterized as stilbenoids oligomers, and were proved to be strong alphaglucosidase inhibitors by inhibitory assay in-vitro. Among them, 3 stilbenoids trimers were reported to be potent α-glucosidase inhibitors for the first time. This method could be modified and have the potential for rapidly screening of active compounds extracts against some new targets by immobilizing some other biomacromolecules.

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    • Cite

    APA: Copy

    Deng, Shiren, Xia, Linbo, Zhu, Xiamin, ZHU, JIANG, Cai, Mingchen, & WANG, XIN. (2019). Natural Alpha-Glucosidase Inhibitors Rapid Fishing from Cyperus Rotundus Using Immobilized Enzyme Affinity Screening Combined with UHPLC-QTOF MS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(3), 1508-1515. SID. https://sid.ir/paper/289168/en

    Vancouver: Copy

    Deng Shiren, Xia Linbo, Zhu Xiamin, ZHU JIANG, Cai Mingchen, WANG XIN. Natural Alpha-Glucosidase Inhibitors Rapid Fishing from Cyperus Rotundus Using Immobilized Enzyme Affinity Screening Combined with UHPLC-QTOF MS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(3):1508-1515. Available from: https://sid.ir/paper/289168/en

    IEEE: Copy

    Shiren Deng, Linbo Xia, Xiamin Zhu, JIANG ZHU, Mingchen Cai, and XIN WANG, “Natural Alpha-Glucosidase Inhibitors Rapid Fishing from Cyperus Rotundus Using Immobilized Enzyme Affinity Screening Combined with UHPLC-QTOF MS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 3, pp. 1508–1515, 2019, [Online]. Available: https://sid.ir/paper/289168/en

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