مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

421
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

172
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CHRONIC ASPIRATION OF GASTRIC AND DUODENAL CONTENTS AND THEIR EFFECTS ON INFLAMMATORY CYTOKINE PRODUCTION IN RESPIRATORY SYSTEM OF RATS

Pages

  40-46

Abstract

 Gastroesophageal reflux disease (GERD) is defined with clinical symptoms of heart burning and regurgitation. It may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic LUNG disease, sinusitis and pulmonary fibrosis. In the present study, rats with chronic aspiration of gastroduodenal contentswere studied for cellular phenotypes and cytokine concentrations in BRONCHOALVEOLAR LAVAGE and LUNG tissue.Thirty-six male Albino N-MRI rats were randomly divided into six groups. After anesthesia and tracheal intubation, the animals received either 0.5ml/kg of normal saline (control), gastric juice, pepsin, hydrochloric acid or bile salts by injection into their LUNGs twice a week for 8 weeks. In sham group nothing was injected. Thereafter, cellular phenotypes and cytokine concentrations of Interleukine (IL) -1a, IL-1b, Transforming Growth Factor (TGF) -b, Tumor Necrosis Factor (TNF) a., and IL-6 were assessed in BRONCHOALVEOLAR LAVAGE and LUNG tissue homogenates.The numbers of epithelial CELLS, macrophages, neutrophils and lymphocytes in BAL and levels of CYTOKINES IL-1a, IL-6, TNFa. and TGF-b in BAL and LUNG tissue of test groups were significantly higher than the control group. Aspiration of bile salts caused more cytokine levels and INFLAMMATORY CELLS compared to other reflux components.It can be concluded that GERD with increased CYTOKINES and INFLAMMATORY CELLS in LUNG could cause or exacerbate asthma and pulmonary fibrosis.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SAMAREH FEKRI, MITRA, POURSALEHI, HAMID REZA, NAJAFIPOUR, HAMID, SHAHOUZAHI, BEYDOLAH, & BAZARGAN HARANDI, NASRIN. (2014). CHRONIC ASPIRATION OF GASTRIC AND DUODENAL CONTENTS AND THEIR EFFECTS ON INFLAMMATORY CYTOKINE PRODUCTION IN RESPIRATORY SYSTEM OF RATS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 13(1), 40-46. SID. https://sid.ir/paper/291375/en

    Vancouver: Copy

    SAMAREH FEKRI MITRA, POURSALEHI HAMID REZA, NAJAFIPOUR HAMID, SHAHOUZAHI BEYDOLAH, BAZARGAN HARANDI NASRIN. CHRONIC ASPIRATION OF GASTRIC AND DUODENAL CONTENTS AND THEIR EFFECTS ON INFLAMMATORY CYTOKINE PRODUCTION IN RESPIRATORY SYSTEM OF RATS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2014;13(1):40-46. Available from: https://sid.ir/paper/291375/en

    IEEE: Copy

    MITRA SAMAREH FEKRI, HAMID REZA POURSALEHI, HAMID NAJAFIPOUR, BEYDOLAH SHAHOUZAHI, and NASRIN BAZARGAN HARANDI, “CHRONIC ASPIRATION OF GASTRIC AND DUODENAL CONTENTS AND THEIR EFFECTS ON INFLAMMATORY CYTOKINE PRODUCTION IN RESPIRATORY SYSTEM OF RATS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 13, no. 1, pp. 40–46, 2014, [Online]. Available: https://sid.ir/paper/291375/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button