مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

IMMUNOMODULATORY EFFECTS OF HUMAN UMBILICAL CORD WHARTON’S JELLY-DERIVED MESENCHYMAL STEM CELLS ON DIFFERENTIATION, MATURATION AND ENDOCYTOSIS OF MONOCYTE-DERIVED DENDRITIC CELLS

Pages

  37-49

Abstract

 The WHARTON’S JELLY of the umbilical cord is believed to be a source of MESENCHYMAL STEM CELLS (MSCs) which can be therapeutically applied in degenerative diseases.In this study, we investigated the immunomodulatory effect of umbilical cord derivedmesenchymal stem cells (UC-MSCs) and BONE MARROW-derived-mesenchymal stem cells (BM-MSCs) on differentiation, maturation, and ENDOCYTOSIS of monocyte-derived DENDRITIC CELLs in a transwell culture system under laboratory conditions. Monocytes were differentiated into immature DENDRITIC CELLs (iDCs) in the presence of GM-CSF and IL-4 for 6 days and then differentiated into mature DENDRITIC CELLs (mDCs) in the presence of TNF-a for 2 days. In every stage of differentiation, immature and mature DENDRITIC CELLs were separately cocultured with UC-MSCs and BM-MSCs.The findings showed that UC-MSCs and BM-MSCs inhibited strongly differentiation and maturation of DENDRITIC CELLs at higher dilution ratios (1: 1). The BM-MSCs and UC-MSCs showed more inhibitory effect on CD1a, CD83, CD86 expression, and DENDRITIC CELL endocytic activity, respectively. On the other hand, these cells severely up-regulated CD14 marker expression.We concluded that UC-MSCs and BM-MSCs could inhibit differentiation, maturation and ENDOCYTOSIS in monocyte-derived DCs through the secreted factors and free of any cellcell contacts under laboratory conditions. As DCs are believed to be the main antigen presenting cells for naïve T cells in triggering immune responses, it would be logical that their inhibitory effect on differentiation, maturation and function can decrease or modulate immune and inflammatory responses.

Cites

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    • Cite

    APA: Copy

    SAEIDI, MOHSEN, MASOUD, AHMAD, SHAKIBA, YADOLLAH, HADJATI, JAMSHID, MOHYEDDIN BONAB, MANDANA, NICKNAM, MOHAMMAD HOSSEIN, LATIFPOUR, MOSTAFA, & NIKBIN, BEHROOZ. (2013). IMMUNOMODULATORY EFFECTS OF HUMAN UMBILICAL CORD WHARTON’S JELLY-DERIVED MESENCHYMAL STEM CELLS ON DIFFERENTIATION, MATURATION AND ENDOCYTOSIS OF MONOCYTE-DERIVED DENDRITIC CELLS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 12(1), 37-49. SID. https://sid.ir/paper/291405/en

    Vancouver: Copy

    SAEIDI MOHSEN, MASOUD AHMAD, SHAKIBA YADOLLAH, HADJATI JAMSHID, MOHYEDDIN BONAB MANDANA, NICKNAM MOHAMMAD HOSSEIN, LATIFPOUR MOSTAFA, NIKBIN BEHROOZ. IMMUNOMODULATORY EFFECTS OF HUMAN UMBILICAL CORD WHARTON’S JELLY-DERIVED MESENCHYMAL STEM CELLS ON DIFFERENTIATION, MATURATION AND ENDOCYTOSIS OF MONOCYTE-DERIVED DENDRITIC CELLS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2013;12(1):37-49. Available from: https://sid.ir/paper/291405/en

    IEEE: Copy

    MOHSEN SAEIDI, AHMAD MASOUD, YADOLLAH SHAKIBA, JAMSHID HADJATI, MANDANA MOHYEDDIN BONAB, MOHAMMAD HOSSEIN NICKNAM, MOSTAFA LATIFPOUR, and BEHROOZ NIKBIN, “IMMUNOMODULATORY EFFECTS OF HUMAN UMBILICAL CORD WHARTON’S JELLY-DERIVED MESENCHYMAL STEM CELLS ON DIFFERENTIATION, MATURATION AND ENDOCYTOSIS OF MONOCYTE-DERIVED DENDRITIC CELLS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 12, no. 1, pp. 37–49, 2013, [Online]. Available: https://sid.ir/paper/291405/en

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