ASSOCIATION OF TUMOR NECROSIS FACTOR ALPHA 308 G/A POLYMORPHISM WITH ASTHMA IN PAKISTANI POPULATION

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SABA NUSRAT; YUSUF OSMAN; REHMAN SADIA; MUNIR SAEEDA; BASHIR NAGHMAN; MANSOOR ATIKA; RAJA GHAZALA KAUKAB

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Journal Paper

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Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:3 Page(s): 287-291

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Title

ASSOCIATION OF TUMOR NECROSIS FACTOR ALPHA 308 G/A POLYMORPHISM WITH ASTHMA IN PAKISTANI POPULATION

Author(s)

Keywords

ASTHMA

PAKISTANI POPULATION

TNF ALPHA 308

Abstract

ASTHMA is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. The role of tumor necrosis factor-a (TNF-a) in ASTHMA is unclear in PAKISTANI POPULATION. The aim of this study was to assess the relationship between TNF-a -308 polymorphism and ASTHMA.Polymorphism of TNF-a (G-308-A locus; rs 1800629) in 329 ASTHMAtic patients and 151 healthy controls was evaluated. DNA was prepared from blood samples of cases and controls. Samples were genotyped for TNF-a 308 G/A polymorphism.There was no significant difference in the frequency of GG (OR 1.049 with 95% CI 0.68-1.63) and GA (OR 0.987 with 95% CI 0.64-1.53) genotypes of TNF-a-308. The AA genotype was absent in cases and only one AA genotype was observed in the controls.The genetic polymorphism of TNF-a does not seem to be associated with ASTHMA in PAKISTANI POPULATION.

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APA: Copy

SABA, NUSRAT, YUSUF, OSMAN, REHMAN, SADIA, MUNIR, SAEEDA, BASHIR, NAGHMAN, MANSOOR, ATIKA, & RAJA, GHAZALA KAUKAB. (2015). ASSOCIATION OF TUMOR NECROSIS FACTOR ALPHA 308 G/A POLYMORPHISM WITH ASTHMA IN PAKISTANI POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(3), 287-291. SID. https://sid.ir/paper/291446/en

Vancouver: Copy

SABA NUSRAT, YUSUF OSMAN, REHMAN SADIA, MUNIR SAEEDA, BASHIR NAGHMAN, MANSOOR ATIKA, RAJA GHAZALA KAUKAB. ASSOCIATION OF TUMOR NECROSIS FACTOR ALPHA 308 G/A POLYMORPHISM WITH ASTHMA IN PAKISTANI POPULATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(3):287-291. Available from: https://sid.ir/paper/291446/en

IEEE: Copy

NUSRAT SABA, OSMAN YUSUF, SADIA REHMAN, SAEEDA MUNIR, NAGHMAN BASHIR, ATIKA MANSOOR, and GHAZALA KAUKAB RAJA, “ASSOCIATION OF TUMOR NECROSIS FACTOR ALPHA 308 G/A POLYMORPHISM WITH ASTHMA IN PAKISTANI POPULATION,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 3, pp. 287–291, 2015, [Online]. Available: https://sid.ir/paper/291446/en

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