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Information Journal Paper

Title

FIXED CUT-OFF FOR FEV1/FEV6 AND FEV6 IN DETECTION OF OBSTRUCTIVE AND RESTRICTIVE PATTERNS

Pages

  152-156

Abstract

 Background: CHRONIC OBSTRUCTIVE PULMONARY DISEASEs (COPD) have been defined by the Global Initiative for CHRONIC OBSTRUCTIVE Lung Disease (GOLD) as irreversible conditions which are diagnosed by fixed cut-off points of FEV1/FVC.Objective: The aim of this study was to determine the cut-off points for FEV1/FEV6 ratio and FEV6 as alternatives for FEV1/FVC and FVC in detection of airway obstruction and lung restriction, respectively.Materials and Methods: A total of 318 Spiro metric examinations of subjects referred to Shariati hospital were analyzed. A subject was considered to have obstruction if FEV1/FVC was lower than 70%. The restriction was defined as FVC dlt; 80% in the absence of obstruction. The Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of FEV1/FEV6 and FEV6 were calculated.Results: This study shows that the current cut-off points used to detect obstruction and restriction can be replaced by FEV1/FEV6 dlt; 71% and FEV6 dlt; 83%, respectively. FEV1/FEV6 had sensitivity of 95.5% and specificity of 99.4%; the PPV and NPVs were 99.3% and 96.3%. The prevalence of obstruction was 49.4%. For restrictive pattern, FEV6 had sensitivity of 93%, specificity of 79.5% with PPV of 18% and NPV of 99.5%. The prevalence of restriction was 6.3%.Conclusions: The FEV1/FEV6 ratio can be used as a valid surrogate for FEV1/FVC in the diagnosis of airway obstruction, especially for screening purposes in high-risk populations for COPD. Moreover, FEV6 is an acceptable alternative for FVC in detection of restrictive pattern.

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    • Cite

    APA: Copy

    AGHILI, ROKHSAREH, KIA, MARYAM, MEYSAMIE, ALIPASHA, AGHILI, SEYED MOJTABA, & PAKNEJAD, OMALBANIN. (2013). FIXED CUT-OFF FOR FEV1/FEV6 AND FEV6 IN DETECTION OF OBSTRUCTIVE AND RESTRICTIVE PATTERNS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(2), 152-156. SID. https://sid.ir/paper/292819/en

    Vancouver: Copy

    AGHILI ROKHSAREH, KIA MARYAM, MEYSAMIE ALIPASHA, AGHILI SEYED MOJTABA, PAKNEJAD OMALBANIN. FIXED CUT-OFF FOR FEV1/FEV6 AND FEV6 IN DETECTION OF OBSTRUCTIVE AND RESTRICTIVE PATTERNS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(2):152-156. Available from: https://sid.ir/paper/292819/en

    IEEE: Copy

    ROKHSAREH AGHILI, MARYAM KIA, ALIPASHA MEYSAMIE, SEYED MOJTABA AGHILI, and OMALBANIN PAKNEJAD, “FIXED CUT-OFF FOR FEV1/FEV6 AND FEV6 IN DETECTION OF OBSTRUCTIVE AND RESTRICTIVE PATTERNS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 2, pp. 152–156, 2013, [Online]. Available: https://sid.ir/paper/292819/en

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