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Title

COMPARISON OF ONDANSETRON AND MEPERIDINE FOR TREATMENT OF POSTOPERATIVE SHIVERING: A RANDOMIZED CONTROLLED CLINICAL TRIAL

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Abstract

 Background: The involved neurotransmitter pathways in the postoperative SHIVERING (POS) are poorly understood. Recently, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists have been reported to prevent POS. We investigated the effect of ONDANSETRON, a 5-HT3 antagonist that is used to treat postoperative nausea and vomiting, on SHIVERING.Objectives: This study aimed to compare the efficacy of ONDANSETRON and MEPERIDINE in the treatment of SHIVERING after general anesthesia.Patients and Methods: In this double-blinded randomized clinical trial, 83 patients (age range, 18-60 years) who had SHIVERING after general anesthesia were randomly allocated to any of these three groups: Group A, (number=27) received 4 mg of intravenous ONDANSETRON, Group B, (number=27) received 8 mg of intravenous ONDANSETRON, and Group C, (number=29) received 0.4 mg/kg of intravenous MEPERIDINE at recovery room. The surface temperatures and the incidence as well as intensity of SHIVERING were recorded.Results: SHIVERING was controlled in 16 patients (59%) in Group A, 22 (81%) in Group B, and 25 (86%) in Group C (P=0.01). Within each group, there were no significant differences among the surface temperature in recovery room. Patients in groups A and B had significantly lower incidence of nausea and vomiting than group C (P=0.01).Conclusions: ONDANSETRON and MEPERIDINE have similar effects on SHIVERING. We concluded that 8 mg of intravenous ONDANSETRON can control SHIVERING and this is the dose of choice, especially in patients with POS with nausea and vomiting.

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    APA: Copy

    MAHOORI, ALIREZA, NOROOZINIA, HEYDAR, HASSANI, EBRAHIM, & SOLTANAHMADI, MARYAM. (2014). COMPARISON OF ONDANSETRON AND MEPERIDINE FOR TREATMENT OF POSTOPERATIVE SHIVERING: A RANDOMIZED CONTROLLED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 16(8), 0-0. SID. https://sid.ir/paper/292920/en

    Vancouver: Copy

    MAHOORI ALIREZA, NOROOZINIA HEYDAR, HASSANI EBRAHIM, SOLTANAHMADI MARYAM. COMPARISON OF ONDANSETRON AND MEPERIDINE FOR TREATMENT OF POSTOPERATIVE SHIVERING: A RANDOMIZED CONTROLLED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2014;16(8):0-0. Available from: https://sid.ir/paper/292920/en

    IEEE: Copy

    ALIREZA MAHOORI, HEYDAR NOROOZINIA, EBRAHIM HASSANI, and MARYAM SOLTANAHMADI, “COMPARISON OF ONDANSETRON AND MEPERIDINE FOR TREATMENT OF POSTOPERATIVE SHIVERING: A RANDOMIZED CONTROLLED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 16, no. 8, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/292920/en

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