PREVALENCE OF MERKEL CELL POLYOMAVIRUS IN TEHRAN: AN AGE-SPECIFIC SEROLOGICAL STUDY

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VAHABPOUR ROUHOLLAH; AGHASADEGHI MOHAMMAD REZA; SALEHI VAZIRI MOSTAFA; MOHAJEL NASIR; KEYVANI HOSSEIN; NASIMI MARYAM; ESGHAEI MARYAM; MONAVARI SEYED HAMIDREZA

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:5 Page(s): 0-0

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Title

PREVALENCE OF MERKEL CELL POLYOMAVIRUS IN TEHRAN: AN AGE-SPECIFIC SEROLOGICAL STUDY

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Keywords

MERKEL CELL POLYOMAVIRUS

VIRUS-LIKE PARTICLE

ENZYME-LINKED IMMUNOSORBET ASSAY

Abstract

Background: Several new types of polyomavirus have been discovered in recent years mainly because of the recent state-of-the-art detection technologies. Among the polyomaviruses, MERKEL CELL POLYOMAVIRUS (MCPyV) has attracted the most attention because of its possible role in the etiology of Merkel cell carcinoma, a rare but lethal form of skin cancer.Objectives: This study aimed to determine age-specific seroprevalence of MCPyV in Tehran.Patients and Methods: In this cross-sectional study, we collected 440 serum samples from healthy individuals 2 to 78 years of age who visited the Pasteur Institute’s clinic in Tehran, Iran, using a convenience sampling strategy. We developed a VIRUS-LIKE PARTICLE-based enzyme-linked immunosorbent assay that uses VP1, the major capsid protein of MCPyV, to detect and quantitate serum antibodies to MCPyV. We compared the prevalence of MCPyV between males and females and across eight age groups.Results: A total of 255 (57.9%) of the serum samples were MCPyV positive. The seroprevalence in children under 10 years of age was 25%. The seroprevalence increased to 56% over the next decade of life (10 - 19 years of age). The seroprevalence rate in males and females was 56.1% and 59.7% respectively, and a binary logistic regression showed no significant difference between males and females (P=0.77). However, the prevalence of MCPyV increased with age (P=0.012).Conclusions: Our results suggest that human exposure to MCPyV occurs throughout life. The MCPyV antibody levels remained high among older adults in our population, consistent with reports from other populations.

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APA: Copy

VAHABPOUR, ROUHOLLAH, AGHASADEGHI, MOHAMMAD REZA, SALEHI VAZIRI, MOSTAFA, MOHAJEL, NASIR, KEYVANI, HOSSEIN, NASIMI, MARYAM, ESGHAEI, MARYAM, & MONAVARI, SEYED HAMIDREZA. (2016). PREVALENCE OF MERKEL CELL POLYOMAVIRUS IN TEHRAN: AN AGE-SPECIFIC SEROLOGICAL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(5), 0-0. SID. https://sid.ir/paper/293298/en

Vancouver: Copy

VAHABPOUR ROUHOLLAH, AGHASADEGHI MOHAMMAD REZA, SALEHI VAZIRI MOSTAFA, MOHAJEL NASIR, KEYVANI HOSSEIN, NASIMI MARYAM, ESGHAEI MARYAM, MONAVARI SEYED HAMIDREZA. PREVALENCE OF MERKEL CELL POLYOMAVIRUS IN TEHRAN: AN AGE-SPECIFIC SEROLOGICAL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(5):0-0. Available from: https://sid.ir/paper/293298/en

IEEE: Copy

ROUHOLLAH VAHABPOUR, MOHAMMAD REZA AGHASADEGHI, MOSTAFA SALEHI VAZIRI, NASIR MOHAJEL, HOSSEIN KEYVANI, MARYAM NASIMI, MARYAM ESGHAEI, and SEYED HAMIDREZA MONAVARI, “PREVALENCE OF MERKEL CELL POLYOMAVIRUS IN TEHRAN: AN AGE-SPECIFIC SEROLOGICAL STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293298/en

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