مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF TOPICAL MORPHINE ON CUTANEOUS LEISHMANIASIS IN AN ANIMAL MODEL: A PRELIMINARY REPORT

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  0-0

Abstract

 Background: Pentavalent antimonials remain the choice of treatment for leishmaniasis, despite their toxicity, high cost, and difficult administration. As an alternative, morphine may induce the healing process of CUTANEOUS LEISHMANIASIS by its immunoregulatory characteristics.Objectives: To study the effect of morphine on the wound-healing process of CUTANEOUS LEISHMANIASIS (CL) in a mouse model.Materials and Methods: This was an experimental study in which 40 BALB/C MICE (female, 6 - 8 weeks) were divided into four groups (each n=10) who received either placebo alone (group 1), morphine ointment after parasite inoculation (group 2), morphine ointment after wound occurrence (group 3), or placebo after wound occurrence (group 4). Wound size was measured weekly for eight weeks.Results: On the first day of treatment, the lesions measured 1.5mmin diameter. After eight weeks of treatment, the wound size was significantly smaller in the MICE who received morphine ointment (4.81±3.22 mm) compared to those who received placebo after parasite inoculation (8.95±5.71 mm; P=0.0001) or placebo after wound occurrence (P=0.028).Conclusions: The above data suggest that topical application of morphine accelerates the healing process of CL wounds. We are cautiously optimistic that the results of this study can be used clinically for potentiating CL wound-healing.

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    APA: Copy

    GHAFFARPASAND, FARIBORZ, AKBARZADEH, AFSOON, HEIRAN, HAMID REZA, KARIMI, ALI ASGHAR, AKBARZADEH, ARMIN, & GHOBADIFAR, MOHAMED AMIN. (2016). EFFECT OF TOPICAL MORPHINE ON CUTANEOUS LEISHMANIASIS IN AN ANIMAL MODEL: A PRELIMINARY REPORT. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(5), 0-0. SID. https://sid.ir/paper/293306/en

    Vancouver: Copy

    GHAFFARPASAND FARIBORZ, AKBARZADEH AFSOON, HEIRAN HAMID REZA, KARIMI ALI ASGHAR, AKBARZADEH ARMIN, GHOBADIFAR MOHAMED AMIN. EFFECT OF TOPICAL MORPHINE ON CUTANEOUS LEISHMANIASIS IN AN ANIMAL MODEL: A PRELIMINARY REPORT. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(5):0-0. Available from: https://sid.ir/paper/293306/en

    IEEE: Copy

    FARIBORZ GHAFFARPASAND, AFSOON AKBARZADEH, HAMID REZA HEIRAN, ALI ASGHAR KARIMI, ARMIN AKBARZADEH, and MOHAMED AMIN GHOBADIFAR, “EFFECT OF TOPICAL MORPHINE ON CUTANEOUS LEISHMANIASIS IN AN ANIMAL MODEL: A PRELIMINARY REPORT,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 5, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293306/en

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