مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

EFFECT OF SIX MONTHS OF AEROBIC EXERCISE ON PLASMA INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA AS BREAST CANCER RISK FACTORS IN POSTMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED TRIAL

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Abstract

 Background: Increased physical activity is associated with a reduction in the risk of BREAST CANCER; however, the exact mechanism of the reduction is not yet completely known.Objectives: This study aimed to investigate the effect of six months of AEROBIC EXERCISE on the plasma interleukin (IL) -6 and tumor necrosis factor-alpha (TNF-a) levels as BREAST CANCER risk factors in POSTMENOPAUSAL WOMEN.Patients and Methods: This study was a randomized controlled trial. We randomly assigned 41 postmenopausal, sedentary women aged 50 to 74 to either an exercise or a control group. The intervention involved facility-based AEROBIC EXERCISE (three days/week, at 70 - 80% of the maximum heart rate, for six months).Results: Twenty-seven women completed the study. The plasma IL-6 level decreased by 21.3% in the exercisers and by 6.9% in the controls, and the intervention effect was significant (P=0.001). The plasma TNF-a level decreased by 17.1% and 10.8% in the exercisers and controls, respectively, although the effect of exercise was not statistically significant (P=0.28). Overall, long-term AEROBIC EXERCISE may result in a decreased IL-6 concentration.Conclusions: We suggest that regular AEROBIC EXERCISE can favorably alter the inflammatory profile, which is a known risk factor in BREAST CANCER development, in POSTMENOPAUSAL WOMEN.

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    APA: Copy

    ABDOLLAHPOUR, AZAM, KHOSRAVI, NASIM, ESKANDARI, ZOHREH, & HAGHIGHAT, SHAHPAR. (2017). EFFECT OF SIX MONTHS OF AEROBIC EXERCISE ON PLASMA INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA AS BREAST CANCER RISK FACTORS IN POSTMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(1), 0-0. SID. https://sid.ir/paper/293317/en

    Vancouver: Copy

    ABDOLLAHPOUR AZAM, KHOSRAVI NASIM, ESKANDARI ZOHREH, HAGHIGHAT SHAHPAR. EFFECT OF SIX MONTHS OF AEROBIC EXERCISE ON PLASMA INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA AS BREAST CANCER RISK FACTORS IN POSTMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(1):0-0. Available from: https://sid.ir/paper/293317/en

    IEEE: Copy

    AZAM ABDOLLAHPOUR, NASIM KHOSRAVI, ZOHREH ESKANDARI, and SHAHPAR HAGHIGHAT, “EFFECT OF SIX MONTHS OF AEROBIC EXERCISE ON PLASMA INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR-ALPHA AS BREAST CANCER RISK FACTORS IN POSTMENOPAUSAL WOMEN: A RANDOMIZED CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 1, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293317/en

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