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Information Journal Paper

Title

INVESTIGATION OF THE CHEMICAL COMPOSITION AND DIFFERENT EFFECTS OF A RUMEX DENTATUS METHANOL EXTRACT AGAINST DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES

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Abstract

 Background: The emergence of PSEUDOMONAS AERUGINOSA as a multiple drug resistant bacteria has renewed efforts to identify alternative antibacterial materials, such as medicinal plants.Objectives: The aims of this study were to investigate the antibacterial effects of a Rumex dentatus methanol extract against drug resistant P. aeruginosa isolates and to analyze the chemical composition of this extract.Materials and Methods: Sixty strains of P. aeruginosa were isolated from urine and wound samples and identified using conventional tests, as well as 16S rDNA gene sequencing.Results: The isolates were completely resistant to the tested antibiotics, with minimum inhibitory concentration (MIC) values for CEFTAZIDIME, imipenem, and gentamicin between 256 to>256 mg/mL, 8 to>256 mg/mL, and 64 to>256 mg/mL, respectively. The R.dentatus extract had a broad spectrum activity against all tested isolates and maximum growth inhibition against isolates from burn wound and urinary tract infections occurred at 200 mg/mL (22.43mm and 22.86mm, respectively). The means of the MIC and minimum bactericidal concentration (MBC) values were 25 and 50 mg/mL, respectively. The effects of a combination of the methanol extract and CEFTAZIDIME, imipenem, and gentamicin antibiotics were antagonistic. The GC-MS analysis of the methanol extract revealed a high probable presence percentage of alpha-pinene, sabinene, and eucalyptol (1, 8-cineole) that have confirmed antimicrobial activity.Conclusions: The R. dentatus methanol extract with broad spectrum activity can be viewed as an alternative to antibiotics for treatment of P. aeruginosa infection.

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    APA: Copy

    PEZESHKI NAJAFABADI, MARYAM, MOHAMMADI SICHANI, MARYAM, KAZEMI, MOHAMMAD JAVAD, SHIRSALIMIAN, MOHAMMADSADEGH, & TAVAKOLI, MAJID. (2016). INVESTIGATION OF THE CHEMICAL COMPOSITION AND DIFFERENT EFFECTS OF A RUMEX DENTATUS METHANOL EXTRACT AGAINST DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(12), 0-0. SID. https://sid.ir/paper/293495/en

    Vancouver: Copy

    PEZESHKI NAJAFABADI MARYAM, MOHAMMADI SICHANI MARYAM, KAZEMI MOHAMMAD JAVAD, SHIRSALIMIAN MOHAMMADSADEGH, TAVAKOLI MAJID. INVESTIGATION OF THE CHEMICAL COMPOSITION AND DIFFERENT EFFECTS OF A RUMEX DENTATUS METHANOL EXTRACT AGAINST DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(12):0-0. Available from: https://sid.ir/paper/293495/en

    IEEE: Copy

    MARYAM PEZESHKI NAJAFABADI, MARYAM MOHAMMADI SICHANI, MOHAMMAD JAVAD KAZEMI, MOHAMMADSADEGH SHIRSALIMIAN, and MAJID TAVAKOLI, “INVESTIGATION OF THE CHEMICAL COMPOSITION AND DIFFERENT EFFECTS OF A RUMEX DENTATUS METHANOL EXTRACT AGAINST DRUG RESISTANT PSEUDOMONAS AERUGINOSA ISOLATES,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 12, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293495/en

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