COMPARING THE EFFECT OF GARLIC, ZATARIA MULTIFLORA AND CLOTRIMAZOLE VAGINAL CREAM 2% ON IMPROVEMENT OF FUNGAL VAGINITIS: A RANDOMIZED CONTROLLED TRIAL

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FARSHBAF KHALILI AZIZEH; MOHAMMADI GHALEHBIN BEHNAM; SHAHNAZI MAHNAZ; Asghari Soltan; JAVADZADEH YUSEF; Azghani Payman

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:12 Page(s): 0-0

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Title

COMPARING THE EFFECT OF GARLIC, ZATARIA MULTIFLORA AND CLOTRIMAZOLE VAGINAL CREAM 2% ON IMPROVEMENT OF FUNGAL VAGINITIS: A RANDOMIZED CONTROLLED TRIAL

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Keywords

VAGINITIS

CANDIDIASIS

GARLIC

CLOTRIMAZOLE

HERBAL MEDICINE

Abstract

Background: GARLIC and Zataria multiflora boiss (ZMB) are HERBAL MEDICINEs used traditionally in the treatment of infections, including candidal VAGINITIS.Objectives: This study aimed to examine the effect of GARLIC and ZMB vaginal cream 2%, in the treatment and recurrence of candidal VAGINITIS.Methods: This randomized, double-blinded clinical trial was conducted on240 married women with candidal VAGINITIS. The patients used 5 gr GARLIC, ZMB or CLOTRIMAZOLE vaginal cream 2% daily, for 7 days. Complaints of the patients, clinical observations and laboratory parameters were recorded before treatment, on days 7 and 30, after treatment. The data were analyzed by SPSS v.21 through chi-square, Fisher, ANOVA with repeated measures, McNemar and Kruskal-Wallis tests. A P<0.05 was considered significant.Results: Before treatment, all patients had positive CANDIDIASIS fungi culture, in both groups (100%). The positive culture was 14.1%, 15.2%, 10.3%, respectively, on day 7 after treatment and 2.6%, 0%, 0% on day 30, after treatment with GARLIC, ZMB and CLOTRIMAZOLE, respectively (P<0.001). No significant differences were observed between groups on days 7 (P=0.69) and 30 (P=0.21) after treatment, in culture results. There were no significant differences between groups, in terms of patient complaints and clinical observations before intervention, at days 7 and 30 after treatment (P>0.05). Mean scores of candidal symptoms reduced significantly in all groups at on 7 and 30, after treatment (P<0.001).Conclusions: GARLIC and ZMB vaginal cream 2% can be used as an effective treatment option in cases of drug resistance and, also, by the people who are interested in treating with HERBAL MEDICINEs.

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References

ANTIFUNGAL EFFECT OF ZATARIA MULTIFLORA ESSENCE ON EXPERIMENTALLY CONTAMINATED ACRYL RESIN PLATES WITH CANDIDA ALBICANS

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APA: Copy

FARSHBAF KHALILI, AZIZEH, MOHAMMADI GHALEHBIN, BEHNAM, SHAHNAZI, MAHNAZ, Asghari, Soltan, JAVADZADEH, YUSEF, & Azghani, Payman. (2016). COMPARING THE EFFECT OF GARLIC, ZATARIA MULTIFLORA AND CLOTRIMAZOLE VAGINAL CREAM 2% ON IMPROVEMENT OF FUNGAL VAGINITIS: A RANDOMIZED CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(12), 0-0. SID. https://sid.ir/paper/293497/en

Vancouver: Copy

FARSHBAF KHALILI AZIZEH, MOHAMMADI GHALEHBIN BEHNAM, SHAHNAZI MAHNAZ, Asghari Soltan, JAVADZADEH YUSEF, Azghani Payman. COMPARING THE EFFECT OF GARLIC, ZATARIA MULTIFLORA AND CLOTRIMAZOLE VAGINAL CREAM 2% ON IMPROVEMENT OF FUNGAL VAGINITIS: A RANDOMIZED CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(12):0-0. Available from: https://sid.ir/paper/293497/en

IEEE: Copy

AZIZEH FARSHBAF KHALILI, BEHNAM MOHAMMADI GHALEHBIN, MAHNAZ SHAHNAZI, Soltan Asghari, YUSEF JAVADZADEH, and Payman Azghani, “COMPARING THE EFFECT OF GARLIC, ZATARIA MULTIFLORA AND CLOTRIMAZOLE VAGINAL CREAM 2% ON IMPROVEMENT OF FUNGAL VAGINITIS: A RANDOMIZED CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 12, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293497/en

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