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Information Journal Paper

Title

Immunohistochemical Evaluation of the Effects of Nitrate in Drinking Water on Laminin Alpha-5 Expression in Rat Renal Glomeruli

Pages

  0-0

Keywords

Rat 

Abstract

 Background: Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate is a polyatomic ion with the molecular formula NO3-. Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate poisoning occurs through metabolism in the liver and conversion of Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate to nitrite, which acts as an intermediary. Laminins are high-molecular weight proteins in extracellular matrix, regarded as one of the major components of the basement membrane. Objectives: The current study aimed to evaluate the effects of Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate on Laminin 5 expression in Rat renal glomeruli. Methods: The current interventional study was conducted on 24 male Wistar Rats in Iran during 2014-2016. Samples were randomly divided into four groups as follows: 1) Normal drinking water, 2) Distilled water containing 45 mg/L of Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate, 3) Distilled water containing 100 mg/L of Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate and 4) Distilled water (control). Sample size consisted of 48 Kidneys randomly collected from Rats. Laminin 5 content in renal glomeruli was determined using the immunohistochemistry (IHC) protocol. Data analysis was performed using the Kruskal-Wallis test and the Spearman correlation coefficient; P value below 0. 05 was considered statistically significant. Results: In the study, intensity of reaction to anti-Laminin was not the same in renal glomeruli. While there was no significant difference between the groups one and two (P > 0. 05), a significant difference was observed between the groups three and four (P < 0. 05) in this regard. Conclusions: According to the results of the study, standard amount of Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate in drinking water had no significant impact on Laminin content. On the other hand, exceeded Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">NitRate concentRations limited the distribution of Laminin, leading to potential adverse effects on glomerular basement membrane.

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    APA: Copy

    JALALI, MAHDI, NIKRAVESH, MOHAMMAD REZA, & MOGHADDAM DORAFSHANI, MAHMOUD. (2016). Immunohistochemical Evaluation of the Effects of Nitrate in Drinking Water on Laminin Alpha-5 Expression in Rat Renal Glomeruli. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(12), 0-0. SID. https://sid.ir/paper/293503/en

    Vancouver: Copy

    JALALI MAHDI, NIKRAVESH MOHAMMAD REZA, MOGHADDAM DORAFSHANI MAHMOUD. Immunohistochemical Evaluation of the Effects of Nitrate in Drinking Water on Laminin Alpha-5 Expression in Rat Renal Glomeruli. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(12):0-0. Available from: https://sid.ir/paper/293503/en

    IEEE: Copy

    MAHDI JALALI, MOHAMMAD REZA NIKRAVESH, and MAHMOUD MOGHADDAM DORAFSHANI, “Immunohistochemical Evaluation of the Effects of Nitrate in Drinking Water on Laminin Alpha-5 Expression in Rat Renal Glomeruli,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 12, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293503/en

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