مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

THE RELATIONSHIP BETWEEN CORONARY ARTERY DISEASE AND GENETIC POLYMORPHISMS OF MELANOMA INHIBITORY ACTIVITY 3

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Abstract

 Background: Melanoma Inhibitory Activity 3 regulates the plasma level of LDL cholesterol. The c.3169+315G>A single-nucleotide POLYMORPHISM of the MIA3 gene has been reported to be associated with serum CORONARY ARTERY DISEASE (CAD). However, there have been no studies analyzing the association of this POLYMORPHISM with CAD in Iranian individuals with CAD.Objectives: Therefore, in the present study we have investigated the potential protective effect of the rs3008621 MIA3polymorphism in 188 subjects with and without CAD.Materials and Methods: Genotyping of the MIA3 gene was undertaken using Taq Man real-time PCR in all subjects. Anthropometric and biochemical features, including HDL, LDL, and TG were assessed in all subjects.Results: The CAD patients had significantly (P<0.05) higher BMI and significantly higher levels of TG, LDL, SBP, and DBP, while the level of HDL was lower compared to that of the control group. the MIA3 gene POLYMORPHISM was not associated with CAD in our population sample.Conclusions: The MIA3 POLYMORPHISM is unlikely to play an important role in CAD in the Iranian population. However, further studies are needed in a larger population to confirm this.

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    APA: Copy

    ZAIMKOHAN, HOOSHANG, KERAMATIPOUR, MOHAMMAD, MIRHAFEZ, SEYED REZA, TAVAKKOLY BAZZAZ, JAVAD, TAHOONI, AZADEH, PIRYAEI, MOHAMMAD, GHAYOUR MOBARHAN, MAJID, & GHADERIAN, SEYED MOHAMMAD HOSSEIN. (2016). THE RELATIONSHIP BETWEEN CORONARY ARTERY DISEASE AND GENETIC POLYMORPHISMS OF MELANOMA INHIBITORY ACTIVITY 3. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(9), 0-0. SID. https://sid.ir/paper/293527/en

    Vancouver: Copy

    ZAIMKOHAN HOOSHANG, KERAMATIPOUR MOHAMMAD, MIRHAFEZ SEYED REZA, TAVAKKOLY BAZZAZ JAVAD, TAHOONI AZADEH, PIRYAEI MOHAMMAD, GHAYOUR MOBARHAN MAJID, GHADERIAN SEYED MOHAMMAD HOSSEIN. THE RELATIONSHIP BETWEEN CORONARY ARTERY DISEASE AND GENETIC POLYMORPHISMS OF MELANOMA INHIBITORY ACTIVITY 3. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(9):0-0. Available from: https://sid.ir/paper/293527/en

    IEEE: Copy

    HOOSHANG ZAIMKOHAN, MOHAMMAD KERAMATIPOUR, SEYED REZA MIRHAFEZ, JAVAD TAVAKKOLY BAZZAZ, AZADEH TAHOONI, MOHAMMAD PIRYAEI, MAJID GHAYOUR MOBARHAN, and SEYED MOHAMMAD HOSSEIN GHADERIAN, “THE RELATIONSHIP BETWEEN CORONARY ARTERY DISEASE AND GENETIC POLYMORPHISMS OF MELANOMA INHIBITORY ACTIVITY 3,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 9, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293527/en

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