مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

THE EFFECTS OF NATURAL NANO-SIZED CLINOPTILOLITE AND METFORMIN ON THE LEVELS OF SERUM GLUCOSE, LIPID PROFILE, AND MINERALS IN RATS WITH TYPE 2 DIABETES MELLITUS

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Abstract

 Background: Natural NANO-sized Clinoptilolite (NCLN) as a conventional treatment for TYPE 2 DIABETES MELLITUSmayreduce glucose concentration and improve levels of MINERALS and LIPID profile (LP).Objectives: The aim of this study was to compare the effects of NCLN with METFORMIN (Met) on fasting blood glucose (FBG), LP, levels of the several MINERALS, and body weight (BW) in RATS with high-fat-diet (HFD) /Streptozotocin (STZ) -induced diabetes.Methods: In this experimental study, 33 male Wistar RATS were divide into four groups of A) healthy (n=6), B) diabetic: (1) NCLN (n= 9) 2% of food, (2) diabetic receiving Met (n=9) 100 mg/kg BW/day and (3) diabetic control (DC) (n=9). The diabetic subgroups were fed with an HFD for one month and injected with a single dose of intra-peritoneal STZ (35 mg/kg BW). At the end of the 7th week, FBG, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), LP, and serum levels of some MINERALS were evaluated.Results: There were no significant differences in FBS, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c) amongthe groups, however, high-density lipoprotein cholesterol (HDL-c) level was significantly higher in the DM (32.92 1.14) and NCLN (32.630.73) groups in comparison with the DC group (31.640.78) (P=0.01). The mean score of Cu level in the DM group was significantly different from that in the DC group (2.15 0.48 vs.1.54  0.21; P=0.03). Moreover, Met significantly increased serum level of Ca as compared to the DC group (86.65 10.03; P=0.01). Also, treatment with Met favorably prevented severe weight loss until the last week of treatment.Conclusions: Natural NANO-sized Clinoptilolite and/or Met did not significantly affect levels of serum glucose, MINERALS, and LIPID profile, but a significant increase in HDL-c was observed as a result of NCLNand METFORMIN treatment, and Cuand Ca levels increased only in the METFORMIN group.

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    APA: Copy

    FALLAHNEJAD, HABIB, OMIDI, HOSSEIN, Khorram, Sirous, MESGARI ABBASI, MEHRAN, ASGHARI JAFAR ABADI, MOHAMMAD, & TARIGHAT ESFANJANI, ALI. (). . , (), -. SID. https://sid.ir/paper/293614/en

    Vancouver: Copy

    FALLAHNEJAD HABIB, OMIDI HOSSEIN, Khorram Sirous, MESGARI ABBASI MEHRAN, ASGHARI JAFAR ABADI MOHAMMAD, TARIGHAT ESFANJANI ALI. . [Internet]. ;():-. Available from: https://sid.ir/paper/293614/en

    IEEE: Copy

    HABIB FALLAHNEJAD, HOSSEIN OMIDI, Sirous Khorram, MEHRAN MESGARI ABBASI, MOHAMMAD ASGHARI JAFAR ABADI, and ALI TARIGHAT ESFANJANI, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/293614/en

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