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Information Journal Paper

Title

THE EFFECTS OF L-ARGININE ON OXIDATIVE AND NITROSATIVE STRESS ANDINFLAMMATION FACTORS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI

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Abstract

 Background: HELICOBACTER PYLORI (H. pylori) plays the primary role in increasing OXIDATIVE STRESS and causing stomach INFLAMMATION, peptic ulcers, and gastric malignancy in the infected patients. L-ARGININE (Arg) has antibacterial and anti-inflammatory effects. Objectives: The current study aimed at investigating the beneficial effects of L-ARGININE on INFLAMMATION and OXIDATIVE STRESS inpatients infected with H. pylori with dyspeptic symptoms. Methods: The current randomized, double-blind controlled, clinical trial was conducted on 34 patients with H. pylori infection referredto the center of digestive disorders affiliated to Isfahan University of Medical Sciences, Isfahan, Iran, in order to undergo endoscopyfrom December 2016 to September 2017. Patients were classified into two groups (control and treatment); the control grouponly received triple-drug therapy (including Amoxicillin, Clarithromycin, and Omeprazole), and the treatment group received standardtriple-drug therapy and L-Arg capsules for three weeks. Gastric biopsies and serum samples were taken from all patients beforeand after the study. H. pylori infection was examined by a rapid urease test and antioxidant indices including superoxide dismutase(SOD), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) were evaluated in gastric biopsies. In addition, serumsamples were used to measure the INFLAMMATION FACTORs including interleukin (IL)-8 and tumor necrosis FACTOR (TNF)- . Results: Level of SODactivity increased significantly in the treatment groupcomparedwith that of the control group (4. 91 95. 21 vs. 4. 0 44. 11 IU/mg) (P = 0. 001). In the treatment group, compared with the control group, the level of TAC increased significantly (0. 35 0. 60 vs. 0. 30 0. 9 mM/L) (P = 0. 006) and the level of GPX activity increased significantly in the treatment group compared withthe control group (10. 68  2. 39 vs. 5. 16  2. 12 IU/mg) (P = 0. 000). Regarding the INFLAMMATION FACTOR, IL-8 decreased significantlyin the treatment group compared with the control group (8. 00  1. 94 vs. 10. 28  2. 10 pg/mL) (P = 0. 002); also TNF- decreasedsignificantly in the treatment group compared with the control group (9. 71  2. 69 vs. 12. 24  3. 29 pg/mL) (P = 0. 036), while therewas no significant difference in high sensitivity C-reactive protein (hs-CRP) decrease between the treatment and the control groups(2. 34 1. 28 vs. 3. 04 1. 58 mg/L) (P = 0. 16). Conclusions: Consumption of L-ARGININE increased antioxidant indices and decreased INFLAMMATION in patients infected with H. pylori.

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    APA: Copy

    AMINI, NAZILA, MOVAHEDI, MONIREH, ABOLFATHI, ALI AKBAR, & MAJD, AHMAD. (2018). THE EFFECTS OF L-ARGININE ON OXIDATIVE AND NITROSATIVE STRESS ANDINFLAMMATION FACTORS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(6), 0-0. SID. https://sid.ir/paper/293754/en

    Vancouver: Copy

    AMINI NAZILA, MOVAHEDI MONIREH, ABOLFATHI ALI AKBAR, MAJD AHMAD. THE EFFECTS OF L-ARGININE ON OXIDATIVE AND NITROSATIVE STRESS ANDINFLAMMATION FACTORS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(6):0-0. Available from: https://sid.ir/paper/293754/en

    IEEE: Copy

    NAZILA AMINI, MONIREH MOVAHEDI, ALI AKBAR ABOLFATHI, and AHMAD MAJD, “THE EFFECTS OF L-ARGININE ON OXIDATIVE AND NITROSATIVE STRESS ANDINFLAMMATION FACTORS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 6, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293754/en

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