مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

EFFECTS OF GREEN COFFEE EXTRACT SUPPLEMENTATION ON OXIDATIVE STRESS, SYSTEMIC AND VASCULAR INFLAMMATION IN PATIENTS WITH METABOLICSYNDROME: A RANDOMIZED CLINICAL TRIAL

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Abstract

 Background: METABOLIC SYNDROME (Mets) is accompanied by OXIDATIVE STRESS and low-grade INFLAMMATION. Green coffee is rich inpolyphenols called CHLOROGENIC ACIDs (CGA), which possess anti-inflammatory and anti-oxidative characteristics. Objectives: The aim of this study was to evaluate the effects of green coffee extract (GCE) on the OXIDATIVE STRESS as well as the systemicand vascular INFLAMMATION in patients having Mets. Methods: This randomized clinical trial was conducted in 2016 in Iran. Forty-three individuals (21 in the intervention and 22 inthe control group) with Mets were randomly assigned to take 400 mg GCE supplements twice a day in the intervention group orplacebo capsules in the control group for 8-weeks. The serum levels of intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were evaluated at the beginning and 8-weeks after theintervention. Results: No significant discrepancy was observed regarding serum levels of IL-6, MDA, hs-CRP, and ICAM-1 between the interventionand control group at the beginning and the end of the trial. After eight weeks of intervention, the mean changes of IL6 in thetreatment and the placebo group were respectively (-0. 73 2. 65 VS 1. 70 10. 51 Pg/mL, P value = 0. 3), hs-CRP (-0. 28 3. 12 VS-0. 08 4. 15mg/L, P value = 0. 86), MDA (0. 44  1. 68 VS 0. 32  2. 28  mol/L, P value = 0. 84), and ICAM-1 (-0. 05  0. 45 VS 0. 02  0. 45ng/mL, Pvalue = 0. 54). Conclusions: In this trial, the green coffee extract (GCE) administration did not affect OXIDATIVE STRESS, systemic, and vascular INFLAMMATIONin subjects with METABOLIC SYNDROME.

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    APA: Copy

    NIKPAYAM, OMID, ROSHAN, HANIEH, SOHRAB, GOLBON, & SEDAGHAT, MEGHDAD. (2018). EFFECTS OF GREEN COFFEE EXTRACT SUPPLEMENTATION ON OXIDATIVE STRESS, SYSTEMIC AND VASCULAR INFLAMMATION IN PATIENTS WITH METABOLICSYNDROME: A RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(6), 0-0. SID. https://sid.ir/paper/293756/en

    Vancouver: Copy

    NIKPAYAM OMID, ROSHAN HANIEH, SOHRAB GOLBON, SEDAGHAT MEGHDAD. EFFECTS OF GREEN COFFEE EXTRACT SUPPLEMENTATION ON OXIDATIVE STRESS, SYSTEMIC AND VASCULAR INFLAMMATION IN PATIENTS WITH METABOLICSYNDROME: A RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(6):0-0. Available from: https://sid.ir/paper/293756/en

    IEEE: Copy

    OMID NIKPAYAM, HANIEH ROSHAN, GOLBON SOHRAB, and MEGHDAD SEDAGHAT, “EFFECTS OF GREEN COFFEE EXTRACT SUPPLEMENTATION ON OXIDATIVE STRESS, SYSTEMIC AND VASCULAR INFLAMMATION IN PATIENTS WITH METABOLICSYNDROME: A RANDOMIZED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 6, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293756/en

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