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Information Journal Paper

Title

TOXOPLASMA GONDII: THE PREVALENCE AND RISK FACTORS IN HIV-INFECTEDPATIENTS IN FARS PROVINCE, SOUTHERN IRAN

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  0-0

Abstract

 Background: Toxoplasma gondii is a zoonotic protozoan that threatens the health of the people infected with human immunodeficiencyvirus (HIV). HIV-positive subjects are at risk of cerebral TOXOPLASMOSIS. Objectives: The current study was designed to find out the seroprevalence of TOXOPLASMOSIS in HIV-infected individuals in Farsprovince, in the South of Iran. Methods: This cross-sectional study was performed on 251 HIV-infected individuals referred to Shiraz HIV/AIDS Research Centerin Fars province, Southern Iran, in 2016. Blood samples (5 mL) were collected from each individual and sera as well as buffy coatwere isolated from each sample. Demographic and HIV-associated data were obtained from the patients’ medical records. Anti-Toxoplasma antibodies (both IgG and IgM) were determined by ELISA, using a commercial kit. In addition, PCR, targeting a 529 bpgene of T. gondii was performed on the patients’ buffy coats for detection of Toxoplasma DNA. Results: Anti-Toxoplasma antibodies were detected in the sera of 42 out of 251 (16. 7%) HIV infected patients. Of these, 39 cases (15. 5%)were seropositive only for IgG and 3 (1. 2%) were positive only for IgM. Seropositive subjects mainly belonged to 40-49 year age group. None of the subjects were positive for Toxoplasma DNA when evaluated by the PCR. No significant associations were found betweenToxoplasma seropositivity and gender, age, and CD4+ cell level (P > 0. 05). Conclusions: Findings of this study demonstrated a significant rate of seroprevalence of Toxoplasma in HIV infected subjects inFars province, Southern Iran. The seropositive cases are at risk of Toxoplasma reactivation and subsequent cerebral encephalitis. Treatment and also prevention of TOXOPLASMOSIS in HIV positive people should be considered.

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    APA: Copy

    AREFKHAH, NASIR, SARKARI, BAHADOR, AFRASHTEH, MASOOD, REZAEI, ZAHRA, & DEHGHANI, MONA. (2018). TOXOPLASMA GONDII: THE PREVALENCE AND RISK FACTORS IN HIV-INFECTEDPATIENTS IN FARS PROVINCE, SOUTHERN IRAN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(6), 0-0. SID. https://sid.ir/paper/293758/en

    Vancouver: Copy

    AREFKHAH NASIR, SARKARI BAHADOR, AFRASHTEH MASOOD, REZAEI ZAHRA, DEHGHANI MONA. TOXOPLASMA GONDII: THE PREVALENCE AND RISK FACTORS IN HIV-INFECTEDPATIENTS IN FARS PROVINCE, SOUTHERN IRAN. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(6):0-0. Available from: https://sid.ir/paper/293758/en

    IEEE: Copy

    NASIR AREFKHAH, BAHADOR SARKARI, MASOOD AFRASHTEH, ZAHRA REZAEI, and MONA DEHGHANI, “TOXOPLASMA GONDII: THE PREVALENCE AND RISK FACTORS IN HIV-INFECTEDPATIENTS IN FARS PROVINCE, SOUTHERN IRAN,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 6, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293758/en

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