مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

COMPARISON OF OXIDATIVE STRESS INTENSITY IN THE SEMINAL PLASMA ANDSERUM OF INFERTILE PATIENTS WITH DIFFERENT VARICOCELE GRADES ANDSUBJECTS WITH NO VARICOCELE: A CROSS-SECTIONAL STUDY

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Abstract

 Background: VARICOCELE is the leading cause of male INFERTILITY throughout the world. Objectives: This study aimed to identify the effects of VARICOCELE on OXIDATIVE STRESS, TOTAL ANTIOXIDANT CAPACITY (TAC), and semenparameters. Methods: In this cross-sectional study, serum and semen samples were collected from subjects with no VARICOCELE (n, 35) and patientswith VARICOCELE (n, 86), who were referred to INFERTILITY and in vitro fertilization (IVF) centers of Babol Clinic Hospital, Babol, Iran during 2015-2016. The semen samples were analyzed according to the world health organization (WHO) guidelines. Afterthe ultrasound and physical examinations, VARICOCELEs were classified into three grades: G1, G2, and G3. TAC and MALONDIALDEHYDE(MDA) levels were measured in the serum and seminal plasma of subjects, using the ferric reducing ability of plasma (FRAP) andthiobarbituric acid reaction (TBAR) methods, respectively. NITRIC OXIDE (NO) was also measured using NITRIC OXIDE assay kit. Results: The mean total SPERM count in the G1, G2, and G3 groups were significantly lower than the control group (P = 0. 037; P =0. 003, and P = 0. 044, respectively). A trend of lower semen volume was observed in the G3 group, compared with the control group(P = 0. 06). A significant positive correlation was observed between elevated serum MDA level and VARICOCELE degree (P < 0. 05). TheMDA level from the highest to the lowest is as follows: G3 > G2 > G1 > controls. There was also a significant negative correlationbetween the serum and seminal plasma TAC levels (P < 0. 05). VARICOCELE patients with G3 degree had a significantly lower meanTAC level in the serum and seminal plasma, compared with the control group (P = 0. 001 and P = 0. 008, respectively). No significantdifference was found in the mean NITRIC OXIDE level between the groups. However, an increasing trend for the mean NITRIC OXIDElevel was observed in the serum and seminal plasma of VARICOCELE patients. Conclusions: The reduced level of seminal plasma antioxidants, which is associated with increased lipid peroxidation, is one of themain reasons for low SPERM quality in patients with VARICOCELE. Antioxidant therapy may be useful in decreasing OXIDATIVE STRESSintensity and improving the condition of VARICOCELE patients.

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    APA: Copy

    YOUSEFNIA PASHA, YOUSEF REZA, MAHJOUB, SOLEIMAN, GHOLAMI, MEHDI, TAHERKHANI, MOSTAFA, BEYKI, ALI ASGHAR, & GHOLINEZHAD, MARYAM. (2018). COMPARISON OF OXIDATIVE STRESS INTENSITY IN THE SEMINAL PLASMA ANDSERUM OF INFERTILE PATIENTS WITH DIFFERENT VARICOCELE GRADES ANDSUBJECTS WITH NO VARICOCELE: A CROSS-SECTIONAL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(6), 0-0. SID. https://sid.ir/paper/293759/en

    Vancouver: Copy

    YOUSEFNIA PASHA YOUSEF REZA, MAHJOUB SOLEIMAN, GHOLAMI MEHDI, TAHERKHANI MOSTAFA, BEYKI ALI ASGHAR, GHOLINEZHAD MARYAM. COMPARISON OF OXIDATIVE STRESS INTENSITY IN THE SEMINAL PLASMA ANDSERUM OF INFERTILE PATIENTS WITH DIFFERENT VARICOCELE GRADES ANDSUBJECTS WITH NO VARICOCELE: A CROSS-SECTIONAL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(6):0-0. Available from: https://sid.ir/paper/293759/en

    IEEE: Copy

    YOUSEF REZA YOUSEFNIA PASHA, SOLEIMAN MAHJOUB, MEHDI GHOLAMI, MOSTAFA TAHERKHANI, ALI ASGHAR BEYKI, and MARYAM GHOLINEZHAD, “COMPARISON OF OXIDATIVE STRESS INTENSITY IN THE SEMINAL PLASMA ANDSERUM OF INFERTILE PATIENTS WITH DIFFERENT VARICOCELE GRADES ANDSUBJECTS WITH NO VARICOCELE: A CROSS-SECTIONAL STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 6, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293759/en

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