مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFICACY OF DEXMEDETOMIDINE IN CORONARY ARTERY BYPASS GRAFT SURGERYUNDER CARDIOPULMONARY BYPASS: A RANDOMIZED, DOUBLE-BLINDCLINICAL TRIAL

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Abstract

 Background: In patients undergoing CARDIOPULMONARY BYPASS (CPB) with extracorporeal circulation, the rapid restoration ofblood flow to the ischemic tissue induces cardiac damage termed as myocardial Ischemic Reperfusion (I/R) injury. Objectives: In the current study, the researchers hypothesized that DEXMEDETOMIDINE (DEX) modulates I/R injury in CoronaryArtery BYPASS Graft Surgery (CABG) with CARDIOPULMONARY BYPASS (CPB). Methods: This randomized, double-blind, clinical trial took place in a university affiliated Hospital, Gilan, Iran. From April 2016to March 2017, 114 eligible patients undergoing elective and isolated CABG were randomized to receive either DEX infusion 0. 3 to0. 5  g/kg/hour before induction of anesthesia till 12 hours postoperatively (group D) or normal saline as placebo (group C). Theendpoints were used to assess creatinine phosphokinase-MB (CKMB) and CARDIAC TROPONIN I (CTnI) levels at four measurement timepoints, including baseline (T0) and 6, 12, 24, and 48 hours after the operation (T0-T4). Results: Overall, 114 patients’ data were analyzed; group D (n = 58) and group C (n = 56). No significant differences were foundbetween the two groups, in view of baseline characteristics. Following CPB, a marked increase in CKMB and CTnI plasma levels wasobserved in both groups compared with baseline (P = 0. 0001). Serum CKMB levels increased from 2. 27 0. 59 to 7. 81 1. 39, and 2. 22 0. 64 to 7. 46  1. 25 and CTnI levels from 10. 22  0. 17 to 4. 89  1. 1, and 0. 27  0. 28 to 4. 5  1. 4 in groups C and D, respectively (P= 0. 0001). According to CKMB, there was a significant difference between the two groups at T2 (P = 0. 002) and T3 (P = 0. 0001), andbased on CTnI at T2 (P = 0. 004) and T3 (P = 0. 0001). However, no significant difference was observed at the other measurement pointtimes. No adverse effect was recorded due to this intervention. Conclusions: Perioperative DEX in cardiac surgery appears safe, with properties to alleviate I/R injury. Obviously, future standardtrials are required to find optimal intervention strategies.

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    APA: Copy

    SEDIGHINEJAD, ABBAS, MOHAMMADZADEH JOURYABI, ALI, IMANTALAB, VALI, MIRMANSOURI, ALI, NASSIRI SHEIKHANI, NASSIR, ATRKARROUSHAN, ZAHRA, BIAZAR, GELAREH, & CHAIBAKHSH, YASMIN. (2018). EFFICACY OF DEXMEDETOMIDINE IN CORONARY ARTERY BYPASS GRAFT SURGERYUNDER CARDIOPULMONARY BYPASS: A RANDOMIZED, DOUBLE-BLINDCLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(8), 0-0. SID. https://sid.ir/paper/293796/en

    Vancouver: Copy

    SEDIGHINEJAD ABBAS, MOHAMMADZADEH JOURYABI ALI, IMANTALAB VALI, MIRMANSOURI ALI, NASSIRI SHEIKHANI NASSIR, ATRKARROUSHAN ZAHRA, BIAZAR GELAREH, CHAIBAKHSH YASMIN. EFFICACY OF DEXMEDETOMIDINE IN CORONARY ARTERY BYPASS GRAFT SURGERYUNDER CARDIOPULMONARY BYPASS: A RANDOMIZED, DOUBLE-BLINDCLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(8):0-0. Available from: https://sid.ir/paper/293796/en

    IEEE: Copy

    ABBAS SEDIGHINEJAD, ALI MOHAMMADZADEH JOURYABI, VALI IMANTALAB, ALI MIRMANSOURI, NASSIR NASSIRI SHEIKHANI, ZAHRA ATRKARROUSHAN, GELAREH BIAZAR, and YASMIN CHAIBAKHSH, “EFFICACY OF DEXMEDETOMIDINE IN CORONARY ARTERY BYPASS GRAFT SURGERYUNDER CARDIOPULMONARY BYPASS: A RANDOMIZED, DOUBLE-BLINDCLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 8, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293796/en

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