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Information Journal Paper

Title

EXPRESSION OF LONG NON-CODING RNAS (UCA1 AND CCAT2) IN THE BLOODOF MULTIPLE SCLEROSIS PATIENTS: A CASE-CONTROL STUDY

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Abstract

 Background: Multiple sclerosis (MS) is an autoimmune and multifactorial disease, and its pathogenesis is associated with manygenetic and environmental factors. LONG NON-CODING RNA (lncRNAs) are a group of GENEs that have recently been identified as predisposinggenetic factors for the development of many cancers. Objectives: This is a case– control study to evaluate the expression of two lncRNAs including Urothelial Carcinoma Associated 1(UCA1) and CANCER-ASSOCIATED TRANSCRIPT 2 (CCAT2) in Relapsing-Remitting Multiple Sclerosis (RRMS) patients compared to healthycontrol group. Methods: In this case-control study, the expression of UCA1 and CCAT2 was evaluated in 50RRMSpatients (37 females, 13 males with amean age of 36. 2 2. 9 years) compared to 50 healthy controls (38 females, 12 males with a mean age of 35. 3 2. 1), using the TaqManreal-time PCR technique. This study was conducted during 2017 and 2018 at Shahid Beheshti University of Medical Sciences, Tehran, Iran. Results: There was no significant difference between the overall expression of UCA1 (P = 0. 282) and CCAT2 (P = 0. 983) among the caseand control groups. However, there was a significant difference in the expression of UCA1 in female patients older than 40 years incomparison with healthy age-matched females (P = 0. 013). In addition, there was a significant correlation between the expressionof UCA1 and CCAT2 (P < 0. 0001). Conclusions: These results suggest the synergistic effects of UCA1 and CCAT2 on pathogenic aspects of MS, by affecting cellularsignaling pathways such as WNT and NF-kB.

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    APA: Copy

    Dastmalchi, Romina, OMRANI, MIR DAVOOD, MAZDEH, MEHRDOKHT, ARSANG JANG, SHAHRAM, MOVAFAGH, ABOLFAZL, SAYAD, AREZOU, & TAHERI, MOHAMMAD. (2018). EXPRESSION OF LONG NON-CODING RNAS (UCA1 AND CCAT2) IN THE BLOODOF MULTIPLE SCLEROSIS PATIENTS: A CASE-CONTROL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(8), 0-0. SID. https://sid.ir/paper/293798/en

    Vancouver: Copy

    Dastmalchi Romina, OMRANI MIR DAVOOD, MAZDEH MEHRDOKHT, ARSANG JANG SHAHRAM, MOVAFAGH ABOLFAZL, SAYAD AREZOU, TAHERI MOHAMMAD. EXPRESSION OF LONG NON-CODING RNAS (UCA1 AND CCAT2) IN THE BLOODOF MULTIPLE SCLEROSIS PATIENTS: A CASE-CONTROL STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(8):0-0. Available from: https://sid.ir/paper/293798/en

    IEEE: Copy

    Romina Dastmalchi, MIR DAVOOD OMRANI, MEHRDOKHT MAZDEH, SHAHRAM ARSANG JANG, ABOLFAZL MOVAFAGH, AREZOU SAYAD, and MOHAMMAD TAHERI, “EXPRESSION OF LONG NON-CODING RNAS (UCA1 AND CCAT2) IN THE BLOODOF MULTIPLE SCLEROSIS PATIENTS: A CASE-CONTROL STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 8, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293798/en

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