COMPARATIVE ANALYSIS OF THE EFFECTS OF VASOPERSSIN ANDNOREPINEPHRINE ON THE RENAL FUNCTION IN PATIENTS UNDERGOING CABG; A RANDOMIZED CLINICAL TRIAL

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VAKILI JAFAR; SAMADI NASRIN; HASANPOR DARGAH MOHAMMAD; ISAZADEFAR KHATEREH; MOHAMMADI KABAR SUSAN; MOHAMMAD ZADEH ALIREZA; VAKILI MOHAMMAD RAHIM

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Journal: Iranian Red Crescent Medical Journal Year:2018 | Volume:20 | Issue:8 Page(s): 0-0

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Title

COMPARATIVE ANALYSIS OF THE EFFECTS OF VASOPERSSIN ANDNOREPINEPHRINE ON THE RENAL FUNCTION IN PATIENTS UNDERGOING CABG; A RANDOMIZED CLINICAL TRIAL

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Keywords

CORONARY ARTERY BYPASS

FUNCTION

NOREPINEPHRINE

RENAL FAILURE

VASOPRESSIN

Abstract

Background: CORONARY ARTERY BYPASS grafting (CABG) is one the most common heart operations, in which blood vessels from otherparts of the body, like the saphenous vein, are grafted to the blocked arteries. Due to the widespread use of vasoactive drugs inthe course of surgery, and renal complications of these drugs, we aimed to determine the effect of NOREPINEPHRINE on the renalfunction of patients with CABG, visiting the cardiac surgery ward of a university affiliated hospital in Ardabil, Iran, with the purposeof maintaining renal perfusion and preventing renal dysfunction in patients undergoing CABG. Objectives: This research aimed to determine and compare the effects of VASOPRESSIN and NOREPINEPHRINE on the renal FUNCTION ofpatients undergoing CABG. Methods: This study was a randomized clinical trial. A total of 120 candidates for CABG in a governmental hospital, Iran, duringyears 2016-2017, were randomly assigned into two groups. The patients’ conditions across the two groups were compared regardinghemodynamics during surgery and post-surgical complications, e. g., renal FUNCTION (Bun, Cr, and CLCr), using a researcher madequestionnaire. Results: The results of our study showed that according to repeated measures test, there was no statistically significant differenceduring the intervention (P value > 0. 05). However, the Independent t-test revealed a statistically significant difference betweengroups following CABG, which related to the clearance creatinine level. It indicated higher clearance creatinine level in the NOREPINEPHRINEgroup (72. 83 25. 03 and 78. 16 27. 31) than the VASOPRESSIN group (64. 33 17. 47 and 86. 33 30. 54) (P < 0. 05), however, the groups did not vary significantly from each other in other items. Conclusions: According to the results of the study, it could be stated that probable renal complications during operation can bereduced to some extent in patients undergoing CABG using inotrope and vasopressor drugs such as NOREPINEPHRINE.

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APA: Copy

VAKILI, JAFAR, SAMADI, NASRIN, HASANPOR DARGAH, MOHAMMAD, ISAZADEFAR, KHATEREH, MOHAMMADI KABAR, SUSAN, MOHAMMAD ZADEH, ALIREZA, & VAKILI, MOHAMMAD RAHIM. (2018). COMPARATIVE ANALYSIS OF THE EFFECTS OF VASOPERSSIN ANDNOREPINEPHRINE ON THE RENAL FUNCTION IN PATIENTS UNDERGOING CABG; A RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(8), 0-0. SID. https://sid.ir/paper/293803/en

Vancouver: Copy

VAKILI JAFAR, SAMADI NASRIN, HASANPOR DARGAH MOHAMMAD, ISAZADEFAR KHATEREH, MOHAMMADI KABAR SUSAN, MOHAMMAD ZADEH ALIREZA, VAKILI MOHAMMAD RAHIM. COMPARATIVE ANALYSIS OF THE EFFECTS OF VASOPERSSIN ANDNOREPINEPHRINE ON THE RENAL FUNCTION IN PATIENTS UNDERGOING CABG; A RANDOMIZED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(8):0-0. Available from: https://sid.ir/paper/293803/en

IEEE: Copy

JAFAR VAKILI, NASRIN SAMADI, MOHAMMAD HASANPOR DARGAH, KHATEREH ISAZADEFAR, SUSAN MOHAMMADI KABAR, ALIREZA MOHAMMAD ZADEH, and MOHAMMAD RAHIM VAKILI, “COMPARATIVE ANALYSIS OF THE EFFECTS OF VASOPERSSIN ANDNOREPINEPHRINE ON THE RENAL FUNCTION IN PATIENTS UNDERGOING CABG; A RANDOMIZED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 8, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293803/en

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