CHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS

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HADJZADEH M.R.; PARSAEE H.; SADEGHIAN A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2004 | Volume:18 | Issue:3 Page(s): 277-280

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Information Journal Paper

Title

CHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS

Author(s)

HADJZADEH M.R. | PARSAEE H. | SADEGHIAN A. | Issue Writer Certificate

Keywords

RHEUM RIBS

RHUBARB

HYPERCHOLESTEROLEMIA

Abstract

The effects of ethanolic and aqueous extracts of RHEUM RIBS L. (RR) of the family polygonaceae was studied on serum cholesterol concentration in rabbits. To induce HYPERCHOLESTEROLEMIA, 0.5 g/kg/day of pure cholesterol powder was given orally to each rabbit for two weeks; then cholesterol was halved and each group of animals was treated with a different regimen for another two weeks. Both the ethanolic and the aqueous extracts significantly decreased serum cholesterol conc-entration. The ethanolic extract decreased serum cholesterol by the end of the first and the second week by 43.9% and 59.1% (both p<0.001) respectively; while the cholesterol reduction with aqueous extract was 25.01% (p<0.05) and 43.82% (p<0.01) at the end of the first and the second week of treatment respectively. The ethanolic extract was found to be more potent than the aqueous one. When comp- ared with nicotinic acid as a positive control, the hypocholesterolemic effect of ethanolic extract was significantly higher than that of nicotinic acid. Therefore, we may conclude that RR extracts have hypocholesterolemic effect and thus can be used in the treatment of HYPERCHOLESTEROLEMIA which is the major risk factor of cor-onary heart disease (CHD).

Cites

THE EFFICACY OF RHEUM RIBES L. STALK EXTRACT ON LIPID PROFILE IN HYPERCHOLESTEROLEMIC TYPE II DIABETIC PATIENTS: A RANDOMIZED, DOUBLE-BLIND, PLACEBO - CONTROLLED, CLINICAL TRIAL

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APA: Copy

HADJZADEH, M.R., PARSAEE, H., & SADEGHIAN, A.. (2004). CHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 18(3), 277-280. SID. https://sid.ir/paper/294080/en

Vancouver: Copy

HADJZADEH M.R., PARSAEE H., SADEGHIAN A.. CHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2004;18(3):277-280. Available from: https://sid.ir/paper/294080/en

IEEE: Copy

M.R. HADJZADEH, H. PARSAEE, and A. SADEGHIAN, “CHOLESTEROL LOWERING EFFECT OF RHEUM RIBS IN HYPERCHOLESTEROLEMIC RABBITS,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 18, no. 3, pp. 277–280, 2004, [Online]. Available: https://sid.ir/paper/294080/en

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