STUDING TERATOGENIC AND ABORTIFICANT EFFECTS OF DIFFERENT DOSES OF SAFFRON (CROCUS SATIVUS) DECOCTION IN WHOLE GESTATIONAL PERIOD AND THE 3RD TRIMESTER OF GESTATIONAL PERIOD IN MICE

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ZEYNALI F.; DASHTI M.H.; ANVARI M.; HOSSEINI S.M.; MIRESMAEILI SEYED MOHSEN

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Journal: International Journal of Reproductive BioMedicine Year:2009 | Volume:7 | Issue:SUPPL 2 Page(s): 0-0

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Title

STUDING TERATOGENIC AND ABORTIFICANT EFFECTS OF DIFFERENT DOSES OF SAFFRON (CROCUS SATIVUS) DECOCTION IN WHOLE GESTATIONAL PERIOD AND THE 3RD TRIMESTER OF GESTATIONAL PERIOD IN MICE

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Keywords

SAFFRON (CROCUS SATIVUS)

ABORTION

MORPHOLOGICAL ABNORMALITIES

Abstract

Introduction: Beside several economical benefits, Saffron has been considered as a medicinal plant since ancient times. However there are some evidences about it’s abortificant effects especially in high doses. The aim of present study was to assess the effects of non toxic doses of aqueous saffron decoction (0.8, 0.2, 0.4 %) on ABORTION and congenital disorders in mice.Materials and Methods: In this study 35 female BALB/c mice, weighting 25-30 grams, were randomly divided into 7 equal groups. Breeding of animals were done in the animal house of medical college by keeping the ratio of male: females as 1:5, in each plastic cage. The females were checked daily for vaginal plaque and the day on which the vaginal plaque was observed, was considered as the first day of pregnancy. The pregnant rats were divided into 7 subgroups and placed in separate cages throughout the gestational period and were acclimatized and fed in the same conditions. Animals in control group received tape water but the test groups received different concentrations (0.8, 0.2, 0.4) of aqueous saffron extract in whole gestational period and 3rd trimester throughout the gestational period. In 20th day of pregnancy, animals were anesthetized and their fetuses were extracted through a cesarean section. The placenta was excised, weighed, and the number and placement of implantation sites, Live and dead fetuses and early and late resorptions were recorded. All fetuses were stereo microscopically examined for any MORPHOLOGICAL ABNORMALITIES.Results: According to our findings placental weight and diameter, mean fetal weight, body and tail length and biparietal diameter in all test groups were smaller than those in control group and these differences were significant in animals receiving 0.8% saffron solution and mostly those who were received the decoction in whole gestational period. The mean numbers of resorbed and dead fetuses in test groups were dose dependently greater than control group. Maximum resorbed and dead fetuses were observed in animals receiving 0.8% saffron solution in whole gestational period rather than those received the solution on 3nd trimester.Conclusion: since embryonic implantation occurs in the first gestational trimester, saffron and it’s components may affect this phenomenon and may result in ABORTION. Organogenesis is mostly happens in the 2nd gestational trimester and the effect of saffron specially in high doses may interfere this event and lead to abnormalities such as decrease in tail length and in placenta weight and diameter. All these abnormalities were seen on using the solutions in whole gestational period. No severe special MORPHOLOGICAL ABNORMALITIES were seen in animals received the saffron extracts on 3rd trimester. According to our findings saffron, is not a safe herb for using in gestational period especially in high doses.

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APA: Copy

ZEYNALI, F., DASHTI, M.H., ANVARI, M., HOSSEINI, S.M., & MIRESMAEILI, SEYED MOHSEN. (2009). STUDING TERATOGENIC AND ABORTIFICANT EFFECTS OF DIFFERENT DOSES OF SAFFRON (CROCUS SATIVUS) DECOCTION IN WHOLE GESTATIONAL PERIOD AND THE 3RD TRIMESTER OF GESTATIONAL PERIOD IN MICE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 7(SUPPL 2), 0-0. SID. https://sid.ir/paper/295421/en

Vancouver: Copy

ZEYNALI F., DASHTI M.H., ANVARI M., HOSSEINI S.M., MIRESMAEILI SEYED MOHSEN. STUDING TERATOGENIC AND ABORTIFICANT EFFECTS OF DIFFERENT DOSES OF SAFFRON (CROCUS SATIVUS) DECOCTION IN WHOLE GESTATIONAL PERIOD AND THE 3RD TRIMESTER OF GESTATIONAL PERIOD IN MICE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2009;7(SUPPL 2):0-0. Available from: https://sid.ir/paper/295421/en

IEEE: Copy

F. ZEYNALI, M.H. DASHTI, M. ANVARI, S.M. HOSSEINI, and SEYED MOHSEN MIRESMAEILI, “STUDING TERATOGENIC AND ABORTIFICANT EFFECTS OF DIFFERENT DOSES OF SAFFRON (CROCUS SATIVUS) DECOCTION IN WHOLE GESTATIONAL PERIOD AND THE 3RD TRIMESTER OF GESTATIONAL PERIOD IN MICE,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 7, no. SUPPL 2, pp. 0–0, 2009, [Online]. Available: https://sid.ir/paper/295421/en

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