THE STUDY OF HELICOBACTER PYLORI ERADICATION RATE IN PEPTIC ULCER PATIENTS, (14 DAYS VERSUS 10 DAYS QUADRUPLE THERAPY REGIMEN)

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MANSOUR GHANAEI F.; FORUTAN H.; GHOFRANY H.; AZEMUDEH F.

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Journal: HAKIM RESEARCH JOURNAL Year:2005 | Volume:7 | Issue:4 Page(s): 14-19

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Title

THE STUDY OF HELICOBACTER PYLORI ERADICATION RATE IN PEPTIC ULCER PATIENTS, (14 DAYS VERSUS 10 DAYS QUADRUPLE THERAPY REGIMEN)

Author(s)

MANSOUR GHANAEI F. | FORUTAN H. | GHOFRANY H. | AZEMUDEH F. | Issue Writer Certificate

Keywords

DRUG THERAPYQ3

HELICOBACTER PYLORIQ4

PEPTIC ULCER DISEASEQ4

TREATMENT REGIMENSQ4

Abstract

Introduction: HELICOBACTER PYLORI (HP) is the most common etiologic cause of gastric and duodenal ulcers. HP eradication, may cure PEPTIC ULCER DISEASEs. Optimal regimen should have, an eradication rate superior to 90%, simplicity, short duration, safety and low cost. This study compares the optimal duration (14 days versus 10 days) of furazolidone, amoxicillin, omeprazole, bismuth regimen. Methods: The patients of this study enrolled from gastroenterologic clinic of Imam Khomeini hospital in Tehran and an ambulatory gastroenterologic clinic of Rasht. Patients with endoscopically proven gastric or duodenal ulcer were biopsied and HP infection was diagnosed with giemsa staining and positive rapid urease test. After taking written informed consent, patients were randomly and single-blinded assigned to I4-day and IO-day groups. Treatment regimen for both of them was furazolidone 200 mg/BD, amoxicillin 1 gr/BD, bismuth subcirate 240 mg/BD and omeprazole 20 mg/BD. Drug compliance was determined by pills count. Endoscopy and biopsy were performed 6 to 5 weeks after treatment and HP infection was evaluated Data were analyzed by SPSS/9 soft- ware. Student t- test and Chi-square (χ2 ) were used and P value less than 0.05 was considered significant. Results: 54 patients enrolled in 14-day group and 53 in 10-day group. Two patients of 14-day group were excluded because of drug intolerance. Four patients (two of both groups) did not return for follow up. There were no significant differences between mean age, sex ratio, smokers and clean based ulcers in both groups. Ulcer healing rate was 96.2% in 14-day group and 88.7% in 10-day group after treatment, Hpylori eradication rate was 72.2% in 14-day group versus 67.9% in 10-day group, side effects were seen 62% in 14-day group and 49% in 10-day group that all these differences were not significant. Infection was eradicated in 61.5% and 38.9% of smokers in I4-day and 10-day group, respectively that showed no significant difference. Conclusion: According to this study, there was no significant difference between HP eradication rate of 10-day and I4-day regimen. It is recommended that large comparative trials should be designed to define optimal duration by the aim of superior to 90% eradication.

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APA: Copy

MANSOUR GHANAEI, F., FORUTAN, H., GHOFRANY, H., & AZEMUDEH, F.. (2005). THE STUDY OF HELICOBACTER PYLORI ERADICATION RATE IN PEPTIC ULCER PATIENTS, (14 DAYS VERSUS 10 DAYS QUADRUPLE THERAPY REGIMEN). HAKIM RESEARCH JOURNAL, 7(4), 14-19. SID. https://sid.ir/paper/29552/en

Vancouver: Copy

MANSOUR GHANAEI F., FORUTAN H., GHOFRANY H., AZEMUDEH F.. THE STUDY OF HELICOBACTER PYLORI ERADICATION RATE IN PEPTIC ULCER PATIENTS, (14 DAYS VERSUS 10 DAYS QUADRUPLE THERAPY REGIMEN). HAKIM RESEARCH JOURNAL[Internet]. 2005;7(4):14-19. Available from: https://sid.ir/paper/29552/en

IEEE: Copy

F. MANSOUR GHANAEI, H. FORUTAN, H. GHOFRANY, and F. AZEMUDEH, “THE STUDY OF HELICOBACTER PYLORI ERADICATION RATE IN PEPTIC ULCER PATIENTS, (14 DAYS VERSUS 10 DAYS QUADRUPLE THERAPY REGIMEN),” HAKIM RESEARCH JOURNAL, vol. 7, no. 4, pp. 14–19, 2005, [Online]. Available: https://sid.ir/paper/29552/en

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