STUDY OF ANTIMICROBIAL RESISTANCE OF STREPTOCOCCUS PNEUMONIAE AND PREDICTION OF MIC AND MBC OF SELECTIVE ANTIBIOTICS

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RAJABI A.; SOLTANI RAD M.; BEHZADIANNEZHAD GH.

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Journal Paper

Paper Information

Journal: HAKIM RESEARCH JOURNAL Year:2001 | Volume:3 | Issue:4 Page(s): 316-320

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Information Journal Paper

Title

STUDY OF ANTIMICROBIAL RESISTANCE OF STREPTOCOCCUS PNEUMONIAE AND PREDICTION OF MIC AND MBC OF SELECTIVE ANTIBIOTICS

Author(s)

RAJABI A. | SOLTANI RAD M. | BEHZADIANNEZHAD GH. | Issue Writer Certificate

Keywords

PNEUMOCOCCIQ4

STREPTOCOCCUS PNEUMONIAEQ4

RESISTANCEQ4

Abstract

The evaluation of the RESISTANCE of Streptococcus pneumonia against penicillin, regarding treatment, has gain some importance. For instance the low-resistant strains could be treated by penicillin, but for high-resistant strains a new formula of medication will be needed. In order to study about Pneumococcal RESISTANCE to penicillin and some other antibiotics, samples which obtained from different hospitals, were cultured.Finally, susceptibility tests were performed, using-disc diffusion method, on 66 obtained strains from 100 clinical specimens. The same was carried out for 5 different antibiotics (penicillin, cefazolin, ampicillin, amoxicillin and vancomycin). The minimum inhibitory concentration (MIC) and the minimum bactericidpl concentration (MBC) were measured, using serial dilution method.In the case of Pencillin 47 sensitive strains and 19 high-resistant strains were obtained. No intermediate or low-resistant strains were found. The RESISTANCE against other antibiotics were evaluated as 10.6%, 7.5%, 18.1% and 0.0%, respectively. The study showed that all strains were sensitive to vancomycin except one low resistant strain.

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