ANTIFERTILITY EFFECTS OF CLOBAZAM IN ADULT MALE RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHARIATI M.; KHATAMSAZ M.; BABOLI S.; GHAVAMI M.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2011 | Volume:9 | Issue:SUPPL 1 Page(s): 16-17

Download Full-Text

View:

327

Download:

Cites:

Information Journal Paper

Title

ANTIFERTILITY EFFECTS OF CLOBAZAM IN ADULT MALE RAT

Author(s)

SHARIATI M. | KHATAMSAZ M. | BABOLI S. | GHAVAMI M.A.

Keywords

CLOBAZAM

TESTOSTERONE

GONADOTROPIN

SPERM

Abstract

Introduction: CLOBAZAM is an anticonvulsant drug. Its side effects on reproductive functions have not been sufficiently studied. This study was designed to evaluate the effect of CLOBAZAM on pituitary-gonad axis and SPERMatogenesis in adult male rats.Materials and Methods: 40 adult male rats wistar strain were randomly divided into five groups. Animals in group1 (Control group) were injected with any treatment. Animals in group2 (Sham group) received the three-component solvent (propylenglycol, ethanol and distilled water in a ratio of 5: 2: 3) in a corresponding volume, i.e.1ml/kg.bw.Animals in groups 3, 4, and 5 received CLOBAZAM (dissolved in solvent), respectively, in doses of 2.5, 5, and 10 mg/kg.bw/day i.p. for 21 days. At the end of the study, blood GONADOTROPINs (LH and FSH) levels as well as TESTOSTERONE of rats in five groups were determined. The animals were sacrificed, then, SPERMatogram and histological changes of their testes were studied under light microscope.Results: The results show that in CLOBAZAM treated groups, particular experimental group 3, blood TESTOSTERONE levels were significantly decreased as compared to the control group. Plasma concentrations of LH, FSH assayed and there were no significant differences among the CLOBAZAM treated groups as compared with control group. Body weight in CLOBAZAM treated relatively increased. However, SPERM density and testes weight were not different from those of the control group.Conclusion: These findings indicate that CLOBAZAM has a relative suppressive influence on reproductive function in rats. We suggest that CLOBAZAM directly affects production of TESTOSTERONE in leydig cells or centrally increased estradiol biosynthesis subsequently lowered TESTOSTERONE levels by negative feedback.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

SHARIATI, M., KHATAMSAZ, M., BABOLI, S., & GHAVAMI, M.A.. (2011). ANTIFERTILITY EFFECTS OF CLOBAZAM IN ADULT MALE RAT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 9(SUPPL 1), 16-17. SID. https://sid.ir/paper/295647/en

Vancouver: Copy

SHARIATI M., KHATAMSAZ M., BABOLI S., GHAVAMI M.A.. ANTIFERTILITY EFFECTS OF CLOBAZAM IN ADULT MALE RAT. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2011;9(SUPPL 1):16-17. Available from: https://sid.ir/paper/295647/en

IEEE: Copy

M. SHARIATI, M. KHATAMSAZ, S. BABOLI, and M.A. GHAVAMI, “ANTIFERTILITY EFFECTS OF CLOBAZAM IN ADULT MALE RAT,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 9, no. SUPPL 1, pp. 16–17, 2011, [Online]. Available: https://sid.ir/paper/295647/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops