COMPUTATIONAL MODELING: THE FUTURE OF EXPERIMENTATION

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FAZELI A.R.; BURKITT M.; WALKER D.; ROMANO D.M.

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2011 | Volume:9 | Issue:SUPPL 2 Page(s): 6-7

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Title

COMPUTATIONAL MODELING: THE FUTURE OF EXPERIMENTATION

Author(s)

FAZELI A.R. | BURKITT M. | WALKER D. | ROMANO D.M.

Keywords

COMPUTATIONAL MODELING

SIMULATIONS

REPRODUCTIVE TRACT

Abstract

Computational or in silico modeling is a subset of systems biology that is concerned with integrating large datasets using complex data structures and algorithms to accurately recreate the behaviour of a system. It is used to determine how the internal components of complex biological systems interact with each other and with external systems. COMPUTATIONAL MODELING approaches have been applied to a number of biological systems at a variety of spatial and temporal scales to complement and enhance experimental research. For example COMPUTATIONAL MODELING approaches are currently used in design and development of the next generation of cardiac pacemakers. Despite the attractive prospects of applying COMPUTATIONAL MODELING systems in understanding complex events leading to conception and development of embryo, the application of in silico modeling to reproductive medicine is still in its infancy. In recent years we have tried to advance development of an in silico model of gamete interaction with female REPRODUCTIVE TRACT in our laboratory by creating a 3-D model of oviduct. Integration of this 3-D model with simple sperm movements has created a relatively simple in silico model that can help us to understand sperm transport in the female REPRODUCTIVE TRACT. We hope progression in this field will allow us to create SIMULATIONS that are more complex and incorporate different factors in their predictions of sperm movements. These SIMULATIONS will help us in understanding sperm transport within female REPRODUCTIVE TRACT and will be the first steps in reaching the ultimate goal of this project that is to predict the milieu of REPRODUCTIVE TRACT at the time of conception.

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APA: Copy

FAZELI, A.R., BURKITT, M., WALKER, D., & ROMANO, D.M.. (2011). COMPUTATIONAL MODELING: THE FUTURE OF EXPERIMENTATION. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 9(SUPPL 2), 6-7. SID. https://sid.ir/paper/295823/en

Vancouver: Copy

FAZELI A.R., BURKITT M., WALKER D., ROMANO D.M.. COMPUTATIONAL MODELING: THE FUTURE OF EXPERIMENTATION. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2011;9(SUPPL 2):6-7. Available from: https://sid.ir/paper/295823/en

IEEE: Copy

A.R. FAZELI, M. BURKITT, D. WALKER, and D.M. ROMANO, “COMPUTATIONAL MODELING: THE FUTURE OF EXPERIMENTATION,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 9, no. SUPPL 2, pp. 6–7, 2011, [Online]. Available: https://sid.ir/paper/295823/en

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