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Information Journal Paper

Title

THE EFFECT OF METYROSINE/PREDNISOLONE COMBINATION TO OOPHORECTOMY-INDUCED OSTEOPOROSIS

Pages

  363-372

Abstract

 Background: OSTEOPOROSIS is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue.Objective: It was investigated whether METHYLPREDNISOLONe had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with METYROSINE.Materials and Methods: Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of ALENDRONATE.Results: Oophorectomy induced OSTEOPOROSIS was exacerbated by METHYLPREDNISOLONe. Alentronate prevented ovariectomised induced OSTEOPOROSIS, but it couldn’t prevent METHYLPREDNISOLONe +ovariectomised induced OSTEOPOROSIS in rats.Conclusion: Combined treatment with METHYLPREDNISOLON and METYROSINE was the best treatment for preventing OSTEOPOROSIS but METYROSINE alone couldn’t prevent OSTEOPOROSIS in ovariectomised rats.

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    • Cite

    APA: Copy

    SALMAN, SULEYMAN, KUMBASAR, SERKAN, HACIMUFTUOGLU, AHMET, OZTURK, BERNA, SEVEN, BEDRI, POLAT, BEYZAGUL, GUNDOGDU, CEMAL, DEMIRCI, ELIF, YILDIRIM, KADIR, AKCAY, FATIH, USLU, TURAN, TUNCEL DALOGLU, FERRAH, & SULEYMAN, HALIS. (2012). THE EFFECT OF METYROSINE/PREDNISOLONE COMBINATION TO OOPHORECTOMY-INDUCED OSTEOPOROSIS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(4), 363-372. SID. https://sid.ir/paper/295905/en

    Vancouver: Copy

    SALMAN SULEYMAN, KUMBASAR SERKAN, HACIMUFTUOGLU AHMET, OZTURK BERNA, SEVEN BEDRI, POLAT BEYZAGUL, GUNDOGDU CEMAL, DEMIRCI ELIF, YILDIRIM KADIR, AKCAY FATIH, USLU TURAN, TUNCEL DALOGLU FERRAH, SULEYMAN HALIS. THE EFFECT OF METYROSINE/PREDNISOLONE COMBINATION TO OOPHORECTOMY-INDUCED OSTEOPOROSIS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(4):363-372. Available from: https://sid.ir/paper/295905/en

    IEEE: Copy

    SULEYMAN SALMAN, SERKAN KUMBASAR, AHMET HACIMUFTUOGLU, BERNA OZTURK, BEDRI SEVEN, BEYZAGUL POLAT, CEMAL GUNDOGDU, ELIF DEMIRCI, KADIR YILDIRIM, FATIH AKCAY, TURAN USLU, FERRAH TUNCEL DALOGLU, and HALIS SULEYMAN, “THE EFFECT OF METYROSINE/PREDNISOLONE COMBINATION TO OOPHORECTOMY-INDUCED OSTEOPOROSIS,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 4, pp. 363–372, 2012, [Online]. Available: https://sid.ir/paper/295905/en

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