PREGNANCY RATE AFTER ENDOMETRIAL INJURY IN COUPLES WITH UNEXPLAINED INFERTILITY: A RANDOMIZED CLINICAL TRIAL

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PARSANEZHAD MOHAMMAD EBRAHIM; DADRAS NASRIN; MAHARLOUEI NAJMEH; NEGHAHBAN LEILA; KERAMATI PEGHAH; AMINI MADIHE

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:11 Page(s): 869-874

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Title

PREGNANCY RATE AFTER ENDOMETRIAL INJURY IN COUPLES WITH UNEXPLAINED INFERTILITY: A RANDOMIZED CLINICAL TRIAL

Author(s)

Keywords

INFERTILITY

FEMALE

ENDOMETRIAL INJURY

PREGNANCY

Abstract

Background: Unexplained INFERTILITY is still a challenging issue as to its causes, appropriate management and treatment. Evidence implicates early embryopathy or implantation failure as likely causes.Objective: This study aims to investigate the effect of local ENDOMETRIAL INJURY on PREGNANCY rate in selected unexplained infertile patients.Materials and Methods: This was a randomized clinical trial conducted in Shiraz University INFERTILITY Clinic of Ghadir Hospital. A total of 217 women with unexplained INFERTILITY aged 23-35 years old were randomly divided into two study groups through block randomization. After superovulation by clomiphene-citrate and gonadotropins and when the dominant follicles reached 18-20 mm, patients were randomly assigned to undergo endometrial local injury at posterior uterine wall by piplle endometrial sampling (n=114) or mock pipette biopsy (n=103) during pre-ovulatory days (when spontaneous urinary LH surge was detected). Then all the patients were instructed to follow a regularly timed intercourse.Results: The PREGNANCY rate was significantly higher in the ENDOMETRIAL INJURY group compared to the control group [17.114 (14.9%) vs. 6.103 (5.8%) (OR: 2.83 95% CI: 1.07-7.49, p=0.03]. The abortion rate was comparable between two groups (17.64% vs. 14.28%; p=0.701).Conclusion: Local mechanical injury of the endometrium can enhance the uterine receptivity and facilitates the embryo implantation. This simple, easy, and cost effective procedure is worth considering in selective unexplained INFERTILITY patients who implantation failure is the likely causes of INFERTILITY before complex treatments. This procedure may help reduce psychological tensions and high expenses imposed through such interventions.

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APA: Copy

PARSANEZHAD, MOHAMMAD EBRAHIM, DADRAS, NASRIN, MAHARLOUEI, NAJMEH, NEGHAHBAN, LEILA, KERAMATI, PEGHAH, & AMINI, MADIHE. (2013). PREGNANCY RATE AFTER ENDOMETRIAL INJURY IN COUPLES WITH UNEXPLAINED INFERTILITY: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(11), 869-874. SID. https://sid.ir/paper/296098/en

Vancouver: Copy

PARSANEZHAD MOHAMMAD EBRAHIM, DADRAS NASRIN, MAHARLOUEI NAJMEH, NEGHAHBAN LEILA, KERAMATI PEGHAH, AMINI MADIHE. PREGNANCY RATE AFTER ENDOMETRIAL INJURY IN COUPLES WITH UNEXPLAINED INFERTILITY: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(11):869-874. Available from: https://sid.ir/paper/296098/en

IEEE: Copy

MOHAMMAD EBRAHIM PARSANEZHAD, NASRIN DADRAS, NAJMEH MAHARLOUEI, LEILA NEGHAHBAN, PEGHAH KERAMATI, and MADIHE AMINI, “PREGNANCY RATE AFTER ENDOMETRIAL INJURY IN COUPLES WITH UNEXPLAINED INFERTILITY: A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 11, pp. 869–874, 2013, [Online]. Available: https://sid.ir/paper/296098/en

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