Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome

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Rahsepar Maryam; MAHJOUB SOLEIMAN; ESMAEILZADEH SEDIGHEH; Kanafchian Maryam; GHASEMI MARYAM

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2017 | Volume:15 | Issue:6 Page(s): 345-350

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Title

Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome

Author(s)

Keywords

Polycystic ovary syndrome

Vitamin D

Oxidative stress

Malondialdehyde

Abstract

Background: There is little evidence about antioxidant properties of Vitamin D. Recent studies suggest that Oxidative stress may play a major role in the pathophysiology of Polycystic ovary syndrome (PCOS), but the association of Vitamin D with Oxidative stress is still not known in PCOS. Objective: The goal of the present study was to evaluate the correlation between serum 25-hydroxy Vitamin D and Oxidative stress markers in PCOS group compared to control group. Materials and Methods: 60 PCOS women (20-40 yr old) and 90 healthy women as control group were participated in this case-control study. Fasting serum level of 25-hydroxy Vitamin D 25(OH) D, glucose, insulin, calcium, Malondialdehyde (MDA), protein carbonyl (PC), also homeostasis model assessment for insulin resistance (HOMA-IR) and fasting glucose to insulin ratio (FGIR) were measured. Results: It was found that the mean of serum 25(OH)D was lower in the PCOS group (10. 76± 4. 17) than in the control group (12. 07± 6. 26) but this difference was not statistically significant (p=0. 125). Fasting insulin, HOMA-IR and MDA were significantly higher in the PCOS patients as compared to the controls, whereas PC level did not differ for the two groups (p=0. 156). No significant correlations were found between 25(OH) D levels and Oxidative stress markers (MDA and PC). Conclusion: The findings indicated no significant differences in the serum 25(OH) D levels between the PCOS patients and the matched controls. Also, no correlation was found between the serum Vitamin D levels and Oxidative stress markers in both groups.

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