Association of leptin and insulin resistance in PCOS: A case-controlled study

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NAMAVAR JAHROMI BAHIA; Dabaghmanesh Mohammad Hassan; PARSANEZHAD MOHAMMAD EBRAHIM; Fatehpoor Faranak

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Journal: International Journal of Reproductive BioMedicine Year:2017 | Volume:15 | Issue:7 Page(s): 423-428

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Title

Association of leptin and insulin resistance in PCOS: A case-controlled study

Author(s)

NAMAVAR JAHROMI BAHIA | Dabaghmanesh Mohammad Hassan | PARSANEZHAD MOHAMMAD EBRAHIM | Fatehpoor Faranak | Issue Writer Certificate

Keywords

Leptin

Polycystic ovarian syndrome

Infertility

Insulin resistance

This article extracted from M

thesis

((Faranak Fatehpoor))

Abstract

Background: Endocrine abnormalities related to polycystic ovary Syndrome (PCOS) are important problems. Objective: To compare serum Leptin levels between infertile women with and without PCOS. To rank sensitivity of six indirect methods for detection of Insulin resistance (IR) and to evaluate the association between Leptin and IR in PCOS group. Materials and methods: This Case-controlled study performed on 189 infertile women referred to Shiraz Mother and Child Hospital during 2012-2015. Ninety-nine PCOS cases according to Rotterdam criteria were compared to 90 cases without PCOS. Serum Leptin, body mass index (BMI), several hormones, and their correlation coefficients with Leptin were compared. IR in PCOS women was measured by indirect methods, including fasting blood sugar (FBS), fasting insulin (FI), glucose/insulin, homeostatic model assessment of Insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and MacAuley index. Association between IR and Leptin was evaluated. Independent sample t-test and Pearson’ s test were used. Results: Infertile women with PCOS had higher BMI (26. 47± 3. 62 vs. 24. 82± 5. 18 kg/m2) and serum Leptin levels (41. 79± 187. 89 vs. 19. 38± 12. 57 ng/mL). Leptin showed significant association with weight and BMI in both groups (p<0. 001) and to age in non-PCOS group. HOMA-IR showed the highest rate of IR followed by FI and QUICKI methods. The mean Leptin levels had positive association with IR assessed by HOMA-IR (p<0. 001), QUICKI (p<0. 001), FI (p=. 002), and FBS (p=0. 02). Conclusion: BMI and IR have positive association with serum Leptin in PCOS infertile women. HOMA-IR followed by FI and QUICKI is the most sensitive test for detection of IR.

Cites

Effect of Nigella Sativa Oil Extract on Leptin and Adiponectin in Type 2 Diabetic Patients: A Randomized, Double Blind, Placebo controlled Clinical Trial

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APA: Copy

NAMAVAR JAHROMI, BAHIA, Dabaghmanesh, Mohammad Hassan, PARSANEZHAD, MOHAMMAD EBRAHIM, & Fatehpoor, Faranak. (2017). Association of leptin and insulin resistance in PCOS: A case-controlled study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 15(7), 423-428. SID. https://sid.ir/paper/296415/en

Vancouver: Copy

NAMAVAR JAHROMI BAHIA, Dabaghmanesh Mohammad Hassan, PARSANEZHAD MOHAMMAD EBRAHIM, Fatehpoor Faranak. Association of leptin and insulin resistance in PCOS: A case-controlled study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2017;15(7):423-428. Available from: https://sid.ir/paper/296415/en

IEEE: Copy

BAHIA NAMAVAR JAHROMI, Mohammad Hassan Dabaghmanesh, MOHAMMAD EBRAHIM PARSANEZHAD, and Faranak Fatehpoor, “Association of leptin and insulin resistance in PCOS: A case-controlled study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 15, no. 7, pp. 423–428, 2017, [Online]. Available: https://sid.ir/paper/296415/en

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