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Information Journal Paper

Title

Interleukins in diagnosis of perinatal asphyxia: A systematic review

Pages

  303-314

Abstract

 Background: Biochemical markers including Interleukins (ILs) has been proposed for early Diagnosis of asphyxia. Objective: This study has aimed to systematically review the significance of IL measurements in the Diagnosis of perinatal asphyxia. Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases before 2017 were searched for the following keywords: asphyxia, neonatal, interleukin, and Diagnosis. A total of 13 out of 300 searched papers were finally selected for evaluation. Interleukins under study were IL6 and interleukin 1𝛽 (IL-1𝛽 ). Interleukins had been measured in 10 studies by serum samples, 2 studies by samples of Cerebro Spinal Fluid (CSF), and 1 study by sample of umbilical cord blood. The inclusion criteria were: studies on neonates, with adequate information from the test results and studies using markers other than ILs to detect asphyxia; however, studies with only abstracts available were excluded. Results: Research on the issue suggests that IL6 > 41 Pg/dl has the sensitivity of 84. 88% and the specificity of 85. 43%, whereas IL-1𝛽 > 4. 7 Pg/dl has the sensitivity of 78% and specificity of 83% in the Diagnosis of neonatal asphyxia. Among diagnostic ILs for neonatal asphyxia, combination of IL6 and IL-1𝛽 had the highest sensitivity, that is, 92. 9%. Conclusion: IL6 and IL-1𝛽 of serum samples were used in the early Diagnosis of perinatal asphyxia and are useful predictors for the outcomes of perinatal asphyxia and its intensity. In addition, simultaneous evaluation of IL-1𝛽 and IL6 can improve the sensitivity of the early Diagnosis of perinatal asphyxia.

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    Cite

    APA: Copy

    BOSKABADI, HASSAN, MORADI, ALI, & ZAKERIHAMIDI, MARYAM. (2019). Interleukins in diagnosis of perinatal asphyxia: A systematic review. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 17(5), 303-314. SID. https://sid.ir/paper/296443/en

    Vancouver: Copy

    BOSKABADI HASSAN, MORADI ALI, ZAKERIHAMIDI MARYAM. Interleukins in diagnosis of perinatal asphyxia: A systematic review. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2019;17(5):303-314. Available from: https://sid.ir/paper/296443/en

    IEEE: Copy

    HASSAN BOSKABADI, ALI MORADI, and MARYAM ZAKERIHAMIDI, “Interleukins in diagnosis of perinatal asphyxia: A systematic review,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 17, no. 5, pp. 303–314, 2019, [Online]. Available: https://sid.ir/paper/296443/en

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