DETERMINATION OF SOLUBLE HER-2/NEU (SHER- 2/NEU) IN IRANIAN PATIENTS WITH LUNG CANCER

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GHAYOUMI S.M.A.; AGHA SADEGHI K.; DOROUDCHI M.; GHADERI A.

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Journal Paper

Paper Information

Journal: Iranian Journal of Immunology Year:2006 | Volume:3 | Issue:2 Page(s): 61-65

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Title

DETERMINATION OF SOLUBLE HER-2/NEU (SHER- 2/NEU) IN IRANIAN PATIENTS WITH LUNG CANCER

Author(s)

GHAYOUMI S.M.A. | AGHA SADEGHI K. | DOROUDCHI M. | GHADERI A. | Issue Writer Certificate

Keywords

LUNG CANCER

HER2/NEU

IRAN

Abstract

Background: The HER-2/neu gene is located on chromosome 17q21 and encodes a 185-kDa transmembrane glycoprotein with tyrosine kinase activity reported to be released in soluble form in various malignancies.Objective: To evaluate the clinical value of soluble Her-2/neu as a diagnostic marker in LUNG CANCER. Method: Serum levels of soluble HER-2/neu were measured in 43 patients with LUNG CANCER and 42 age and sex matched controls by an enzyme immunoassay method.Results: Mean serum level of soluble Her-2/neu in cancer patients was 6.07±10.37 ng/ml which was significantly higher than the control group (P < 0.05). Cigarette smoking had no effect on the level of soluble HER-2/neu. A cut off value of 6.1ng/ml revealed a high specificity (95%) for diagnosis of LUNG CANCER, but a very low sensitivity (14%). Conclusion: The results of this study show an increased level of soluble HER-2/neu in the sera of LUNG CANCER patients with a high specificity but low sensitivity for the diagnosis of LUNG CANCERs.

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APA: Copy

GHAYOUMI, S.M.A., AGHA SADEGHI, K., DOROUDCHI, M., & GHADERI, A.. (2006). DETERMINATION OF SOLUBLE HER-2/NEU (SHER- 2/NEU) IN IRANIAN PATIENTS WITH LUNG CANCER. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 3(2), 61-65. SID. https://sid.ir/paper/296746/en

Vancouver: Copy

GHAYOUMI S.M.A., AGHA SADEGHI K., DOROUDCHI M., GHADERI A.. DETERMINATION OF SOLUBLE HER-2/NEU (SHER- 2/NEU) IN IRANIAN PATIENTS WITH LUNG CANCER. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2006;3(2):61-65. Available from: https://sid.ir/paper/296746/en

IEEE: Copy

S.M.A. GHAYOUMI, K. AGHA SADEGHI, M. DOROUDCHI, and A. GHADERI, “DETERMINATION OF SOLUBLE HER-2/NEU (SHER- 2/NEU) IN IRANIAN PATIENTS WITH LUNG CANCER,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 3, no. 2, pp. 61–65, 2006, [Online]. Available: https://sid.ir/paper/296746/en

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