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Information Journal Paper

Title

ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF CAREYA ARBOREA ROXB. STEM BARK

Pages

  35-41

Abstract

 The present study was carried out to evaluate the antimicrobial and antioxidant activities of methanol extract of CAREYA ARBOREA (MECA) stem barks (Myrtaceae) in various in-vitro systems. Antimicrobial activities of MECA were carried out using disc diffusion methods with Gram positive and Gram negative bacteria and some fungal species. MECA showed broad-spectrum ANTIMICROBIAL ACTIVITY against all tested microorganism Antioxidant and FREE RADICAL SCAVENGING activities of MECA was assessed by using 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH), superoxide anion radical, nitric oxide radical and hydroxyl radical scavenging assays. The ANTIOXIDANT ACTIVITY of MECA increased in a concentration dependent manner. In DPPH radical scavenging assay the IC50 value of the extract was found to be 132.25 μg/mL. MECA was found to inhibit the nitric oxide radicals generated from sodium nitroprusside. The IC50 value was found to be 72.54 μg/mL, whereas the IC50 value of curcumin was 20.4 μg/mL. Moreover, the MECA was found to scavenge the superoxide generated by phenazine methosulphate (PMS) / nicotinamide adenine cleotide (NADH)-nitroblue tetrazolium (NBT) system. MECA was also found to inhibit the hydroxyl radical generated by Fenton’s reaction, where the IC50 value of MECA was found to be more than 1000 µg/ml and for catechin the IC50 value was found to be 5 μg/mL. The results obtained in the present study indicate that the MECA can be a potential source of natural antimicrobial and antioxidant agents.

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    Cite

    APA: Copy

    SAMBATH KUMAR, R., SIVAKUMAR, TH., SUNDERAM, R.SH., SIVAKUMAR, P., NETHAJI, R., GUPTA, M., & MAZUMDAR, U.K.. (2006). ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF CAREYA ARBOREA ROXB. STEM BARK. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 5(1), 35-41. SID. https://sid.ir/paper/297105/en

    Vancouver: Copy

    SAMBATH KUMAR R., SIVAKUMAR TH., SUNDERAM R.SH., SIVAKUMAR P., NETHAJI R., GUPTA M., MAZUMDAR U.K.. ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF CAREYA ARBOREA ROXB. STEM BARK. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2006;5(1):35-41. Available from: https://sid.ir/paper/297105/en

    IEEE: Copy

    R. SAMBATH KUMAR, TH. SIVAKUMAR, R.SH. SUNDERAM, P. SIVAKUMAR, R. NETHAJI, M. GUPTA, and U.K. MAZUMDAR, “ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF CAREYA ARBOREA ROXB. STEM BARK,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 5, no. 1, pp. 35–41, 2006, [Online]. Available: https://sid.ir/paper/297105/en

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