مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

NIMODIPINE PROTECTS PC12 CELLS AGAINST OXYGEN-GLUCOSE DEPRIVATION

Pages

  51-54

Abstract

 The protective effect of an L-type calcium channel blocker, NIMODIPINE, on cell injury induced by OXYGEN-GLUCOSE DEPRIVATION (OGD) in PC12 cells was investigated. PC12 cells were exposed to OXYGEN-GLUCOSE DEPRIVATION (30 minutes and 60 minutes respectively) in the presence or absence of NIMODIPINE (10mM/L) in three different time schedules (pre-24h, pre-3h and concurrently). Cellular viability was assessed by MTT assay. OGD-induced cell injury was significantly attenuated by NIMODIPINE in all three treatment schedules. Application of MK801 (10mM/L), an antagonist of NMDA glutamate receptors also inhibited PC12 cell death induced by OGD. Our study suggests that NIMODIPINE has protective effects against OGD-induced neurotoxicity.

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    Cite

    APA: Copy

    RAHBAR ROUSHANDEL, N., RAZAVI, LILI, & TAVAKOLIFAR, B.. (2007). NIMODIPINE PROTECTS PC12 CELLS AGAINST OXYGEN-GLUCOSE DEPRIVATION. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 6(1), 51-54. SID. https://sid.ir/paper/297142/en

    Vancouver: Copy

    RAHBAR ROUSHANDEL N., RAZAVI LILI, TAVAKOLIFAR B.. NIMODIPINE PROTECTS PC12 CELLS AGAINST OXYGEN-GLUCOSE DEPRIVATION. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2007;6(1):51-54. Available from: https://sid.ir/paper/297142/en

    IEEE: Copy

    N. RAHBAR ROUSHANDEL, LILI RAZAVI, and B. TAVAKOLIFAR, “NIMODIPINE PROTECTS PC12 CELLS AGAINST OXYGEN-GLUCOSE DEPRIVATION,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 6, no. 1, pp. 51–54, 2007, [Online]. Available: https://sid.ir/paper/297142/en

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