Designing a DNA Vaccine-based Leishmania major Polytope (Preliminary Report) (Short Communication)

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JEIBOUEI Shabnam; BANDEHPOUR MOJGAN; KAZEMI BAHRAM; HAGHIGHI ALI

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PARASITOLOGY Year:2017 | Volume:12 | Issue:3 Page(s): 441-445

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Information Journal Paper

Title

Designing a DNA Vaccine-based Leishmania major Polytope (Preliminary Report) (Short Communication)

Author(s)

JEIBOUEI Shabnam | BANDEHPOUR MOJGAN | KAZEMI BAHRAM | HAGHIGHI ALI | Issue Writer Certificate

Keywords

DNA vaccine

Polytope

Leishmania major

Abstract

Background: Leishmaniasis is a neglected disease affecting millions of people worldwide. The treatment of the disease is hampered due to high cost, toxicity and the crisis of drug resistance. Polytope approaches of genetic immunization could be a strategy for prevention of infectious diseases. Furthermore, the identification of Leishmania genome sequence and the application of bioinformatics assist us to devise an effective vaccine’ s candidate. Methods: A linear sequence from predicted epitopes of GP63, LACK and CPC antigens was designed and was optimized using online available algorithms. The synthesized sequence (LAKJB93) was ligated to pEGFP-N1 plasmid. Results: The 264bp sequence was cloned at N terminal of GFP into pEGFP_N1 expression vector and transfect into CHO cell line. Construct was efficient expressed in CHO cells. Conclusion: The protein of LAKJB93 cosnstruct was expressed in CHO cells successfully.

Cites

Immunogenicity and Efficacy of Polytope DNA Vaccine Against Cutaneous Leishmaniosis In Vivo

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APA: Copy

JEIBOUEI, Shabnam, BANDEHPOUR, MOJGAN, KAZEMI, BAHRAM, & HAGHIGHI, ALI. (2017). Designing a DNA Vaccine-based Leishmania major Polytope (Preliminary Report) (Short Communication). IRANIAN JOURNAL OF PARASITOLOGY, 12(3), 441-445. SID. https://sid.ir/paper/304220/en

Vancouver: Copy

JEIBOUEI Shabnam, BANDEHPOUR MOJGAN, KAZEMI BAHRAM, HAGHIGHI ALI. Designing a DNA Vaccine-based Leishmania major Polytope (Preliminary Report) (Short Communication). IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2017;12(3):441-445. Available from: https://sid.ir/paper/304220/en

IEEE: Copy

Shabnam JEIBOUEI, MOJGAN BANDEHPOUR, BAHRAM KAZEMI, and ALI HAGHIGHI, “Designing a DNA Vaccine-based Leishmania major Polytope (Preliminary Report) (Short Communication),” IRANIAN JOURNAL OF PARASITOLOGY, vol. 12, no. 3, pp. 441–445, 2017, [Online]. Available: https://sid.ir/paper/304220/en

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