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Information Journal Paper

Title

NITRIC OXIDE-INDUCED POLYCYSTIC OVARIES IN THE WISTAR RAT

Pages

  111-116

Abstract

 Background: NITRIC OXIDE (NO) involves in polycystic ovary syndrome (PCOS), a cause of infertility in women during the reproductive age. The PCOS is now categorized as an inflammatory phenomenon. The aim of this study was to evaluate the role of NO, a proinflammatory agent, in this syndrome at histological and biochemical levels.Materials and Methods: In this experimental study, animals were female Wistar rats (weighing 200-250 g) kept under standard conditions. L-ARGININE (50-200 mg/kg), a precursor of NO, was injected intra-peritoneally (i.p.) through a period ranging from 9 to14 days/ once a day. The rats' estrous cycle was studied using Papanicolaou test; those showing phase of Diestrous were grouped into experimental and control groups. The control group solely received saline (1 ml/kg, i.p.) throughout all experiments. To evaluate the inflammatory effect of NO, the rats were treated an anti-inflammatory agent, NALOXONE hydrochloride (0.4 mg/kg, i.p.), prior to L-ARGININE. At the end of the treatment period all animals’ ovaries were assessed for histopathological and histochemical investigations. Also, activation of NO synthase (NOS) in the experiments was studied using NADPH-DIAPHORASE technique.Results: The ovaries of rats treated with L-ARGININE showed polycystic characteristics in contrast to those collected from control or NALOXONE pretreated groups, based on image analysis. A difference in enzyme activation was also shown in the sections that belonged to the groups that received L-ARGININE when compared with the pre-naloxone and control groups.Conclusion: Based on these results, we believe that NO may play a major role in the pathophysiology of PCOS.

Cites

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    APA: Copy

    HASANI, FATEMEH, KARAMI, MANIZHEH, JALALI NADOUSHAN, MOHAMMADREZA, & EFTEKHARI YAZDI, POOPAK. (2012). NITRIC OXIDE-INDUCED POLYCYSTIC OVARIES IN THE WISTAR RAT. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(2), 111-116. SID. https://sid.ir/paper/305356/en

    Vancouver: Copy

    HASANI FATEMEH, KARAMI MANIZHEH, JALALI NADOUSHAN MOHAMMADREZA, EFTEKHARI YAZDI POOPAK. NITRIC OXIDE-INDUCED POLYCYSTIC OVARIES IN THE WISTAR RAT. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2012;6(2):111-116. Available from: https://sid.ir/paper/305356/en

    IEEE: Copy

    FATEMEH HASANI, MANIZHEH KARAMI, MOHAMMADREZA JALALI NADOUSHAN, and POOPAK EFTEKHARI YAZDI, “NITRIC OXIDE-INDUCED POLYCYSTIC OVARIES IN THE WISTAR RAT,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 6, no. 2, pp. 111–116, 2012, [Online]. Available: https://sid.ir/paper/305356/en

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