VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK

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BAGHERI MORTEZA; ABDI RAD ISA; HOSSEINI JAZANI NIMA; NANBAKHSH FARIBA

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Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2013 | Volume:7 | Issue:2 Page(s): 116-121

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Title

VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK

Author(s)

BAGHERI MORTEZA | ABDI RAD ISA | HOSSEINI JAZANI NIMA | NANBAKHSH FARIBA | Issue Writer Certificate

Keywords

VITAMIN D RECEPTOR

POLYCYSTIC OVARY SYNDROME

GENETIC VARIATION

Abstract

Background: POLYCYSTIC OVARY SYNDROME (PCOS) is known as a metabolic disorder. The results of recent studies implied that VITAMIN D RECEPTOR (VDR) genetic variants may impact PCOS and insulin resistance in women with PCOS. The aim of the present study was to determine the VDR TaqI gene variant in exon 9 (T/C) (rs731236) in normal controls and patients with PCOS for the first time in Iranian Azeri women.Materials and Methods: In this case control study between April 2011 and June 2012, a total of 76 women aged 18-40 years (38 patients with PCOS and 38 healthy women as normal controls) participated. Genotypes of VDR TaqI in exon 9 (T/C) (rs731236) were determined using the PCR-RFLP method.Results: The frequencies of VDR TaqI T anc C alleles were 0.605 and 0.395 in cases and 0.697 and 0.303 in controls. Also, the genotypic frequencies of VDR TaqI were 16) (42.11), 14 (36.84), and 8 (21.05) in cases, and 17 (44.74), 19 (50), and 2 (5.26) in controls for TT, TC and CC genotypes respectively. There was no difference in genotype and allele frequencies between PCOS and controls (p value>0.05) with the exception of the CC genotype (p value=0.04).Conclusion: This report, a first of its own kind in Iranian Azeri patients, suggests that the CC genotype of VDR TaqI in exon 9 (rs731236) is associated with PCOS.

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APA: Copy

BAGHERI, MORTEZA, ABDI RAD, ISA, HOSSEINI JAZANI, NIMA, & NANBAKHSH, FARIBA. (2013). VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 7(2), 116-121. SID. https://sid.ir/paper/305408/en

Vancouver: Copy

BAGHERI MORTEZA, ABDI RAD ISA, HOSSEINI JAZANI NIMA, NANBAKHSH FARIBA. VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2013;7(2):116-121. Available from: https://sid.ir/paper/305408/en

IEEE: Copy

MORTEZA BAGHERI, ISA ABDI RAD, NIMA HOSSEINI JAZANI, and FARIBA NANBAKHSH, “VITAMIN D RECEPTOR TAQI GENE VARIANT IN EXON 9 AND POLYCYSTIC OVARY SYNDROME RISK,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 7, no. 2, pp. 116–121, 2013, [Online]. Available: https://sid.ir/paper/305408/en

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