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Information Journal Paper

Title

PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Pages

  235-242

Abstract

 Background: To assess the efficacy of LUTEAL PHASE support (LPS) using intravaginal PROGESTERONE (P) on pregnancy rate in Iranian women with POLYCYSTIC OVARIAN SYNDROME (PCOS) who used a combination for ovulation induction consisting of LETROZOLE or CLOMIPHENE citrate (CC) and human menopausal gonadotropin (HMG).Materials and Methods: This was a randomized clinical trial undertaken in a fertility clinic in Kashan, Isfahan Province, Iran. A total of 198 patients completed treatment and follow up. Base on chosen ovulation induction programs, they were divided into two following group: i. CC group (n=98) used a combination consisting of CC (100 mg×5 day) and HMG (150 IU×5 day) and ii. LETROZOLE group (n=100) used a combination consisting of LETROZOLE (5 mg×5 day) and HMG (150 IU×5 day). After human chorionic gonadotropin (hCG) administration (5000 IU), the patients (n=122) who randomly received intravaginal P (Cyclogest, 400 mg daily) were included in LPS group, while the rest (n=123) were included in non-P cycles group. The outcome was the comparison of chemical pregnancy rate between the groups.Results: Our findings showed that LPS was associated with a 10% higher pregnancy rate than in non-P cycles, although this difference did not reach statistical significant (p=0.08). LPS improved pregnancy rate in both CC (4%) and LETROZOLE (6%) groups. In addition, patients who used LETROZOLE for ovulation induction along with intravaginal P showed higher pregnancy rates than CC group.Conclusion: Administration of vaginal P for LPS may improve the pregnancy rate in women with PCOS using LETROZOLE or CC in combination with HMG for ovulation induction (Registration Number: IRCT201206072967N4).

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    Cite

    APA: Copy

    FOROOZANFARD, FATEMEH, SABERI, HAMIDREZA, MORAVEJI, SEYED ALIREZA, & BAZARGANIPOUR, FATEMEH. (2014). PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 8(3), 235-242. SID. https://sid.ir/paper/305754/en

    Vancouver: Copy

    FOROOZANFARD FATEMEH, SABERI HAMIDREZA, MORAVEJI SEYED ALIREZA, BAZARGANIPOUR FATEMEH. PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2014;8(3):235-242. Available from: https://sid.ir/paper/305754/en

    IEEE: Copy

    FATEMEH FOROOZANFARD, HAMIDREZA SABERI, SEYED ALIREZA MORAVEJI, and FATEMEH BAZARGANIPOUR, “PREGNANCY RATE FOLLOWING LUTEAL PHASE SUPPORT IN IRANIAN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 8, no. 3, pp. 235–242, 2014, [Online]. Available: https://sid.ir/paper/305754/en

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