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Information Journal Paper

Title

EFFECT OF PHOSALONE ON TESTICULAR TISSUE AND IN VITRO FERTILIZING POTENTIAL

Pages

  93-106

Abstract

 Background: The current study aimed to evaluate the effects of PHOSALONE (PLN) as an organophosphate (OP) compound on TESTICULAR TISSUE, hormonal alterations and embryo development in rats.Materials and Methods: In this experimental study, we divided 18 mature Wistar rats into three groups-control, control-sham and test (n=6 per group). Animals in the test group received one-fourth the lethal dose (LD50) of PLN (150 mg/kg), orally, once per day for 45 days. DNA laddering and epi-fluorescent analyses were performed to evaluate testicular DNA FRAGMENTATION and RNA damage, respectively. Serum levels of testosterone and inhibin-B (IN-B) were evaluated. Testicular levels of total antioxidant capacity (TAC), total thiol molecules (TTM) and glutathione peroxidase (GSH-px) were analyzed. Finally, we estimated SPERM parameters and effect of PLN on embryo development. Two-way ANOVA was used for statistical analyses.Results: There was severe DNA FRAGMENTATION and RNA damage in TESTICULAR TISSUE of animals that received PLN. PLN remarkably (p<0.05) decreased testicular TAC, TTM and GSH-px levels. Animals that received PLN exhibited significantly (p<0.05) decreased serum levels of testosterone and IN-B. Reduced SPERM count, viability, motility, chromatin condensation and elevated SPERM DNA damage were observed in the test group rats. PLN resulted in significant (p<0.05) reduction of in vitro fertilizing (IVF) potential and elevated embryonic degeneration.Conclusion: PLN reduced fertilization potential and embryo development were attributed to a cascade of impacts on the testicles and SPERM. PLN promoted its impact by elevating DNA and RNA damages via down-regulation of testicular endocrine activity and antioxidant status.

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    Cite

    APA: Copy

    AMNIATTALAB, AMIR, & RAZI, MAZDAK. (2015). EFFECT OF PHOSALONE ON TESTICULAR TISSUE AND IN VITRO FERTILIZING POTENTIAL. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 9(1), 93-106. SID. https://sid.ir/paper/305784/en

    Vancouver: Copy

    AMNIATTALAB AMIR, RAZI MAZDAK. EFFECT OF PHOSALONE ON TESTICULAR TISSUE AND IN VITRO FERTILIZING POTENTIAL. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2015;9(1):93-106. Available from: https://sid.ir/paper/305784/en

    IEEE: Copy

    AMIR AMNIATTALAB, and MAZDAK RAZI, “EFFECT OF PHOSALONE ON TESTICULAR TISSUE AND IN VITRO FERTILIZING POTENTIAL,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 9, no. 1, pp. 93–106, 2015, [Online]. Available: https://sid.ir/paper/305784/en

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