RENAL AND HEPATIC FUNCTIONS AFTER A WEEK OF CONTROLLED OVARIAN HYPERSTIMULATION DURING IN VITRO FERTILIZATION CYCLES

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ROMITO ILARIA; ANTONIO GULINO FERDINANDO; LAGANA ANTONIO SIMONE; VITALE SALVATORE GIOVANNI; TUSCANO ATTILIO; LEANZA GIANLUCA; MUSMECI GIULIA; LEANZA VITO; CHIARA RAPISARDA AGNESE MARIA; ANTONIO PALUMBO MARCO

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Journal: International Journal of Fertility & Sterility Year:2017 | Volume:11 | Issue:1 Page(s): 15-19

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Title

RENAL AND HEPATIC FUNCTIONS AFTER A WEEK OF CONTROLLED OVARIAN HYPERSTIMULATION DURING IN VITRO FERTILIZATION CYCLES

Author(s)

Keywords

INFERTILITY

OVARIAN HYPERSTIMULATION

INTRACYTOPLASMIC SPERM INJECTION

IN VITRO FERTILIZATION

Abstract

Background: One the main aspects of IN VITRO FERTILIZATION (IVF) cycle is to avoid any possible systemic damage on women undergoing a controlled OVARIAN HYPERSTIMULATION (COH). The aim of this work is to evaluate renal and hepatic function blood tests in patients undergoing controlled OVARIAN HYPERSTIMULATION during IVF cycles.Materials and Methods: We performed a prospective cohort analysis. All patients received a long stimulation protocol with gonadotropin-releasing hormone (GnRH) analogues by daily administration, since the twenty-first day of the previous ovarian cycle followed by COH with recombinant follicle-stimulating hormone (FSH). The daily dose of exogenous gonadotropins for every single patient was modified according to her follicular growth. The oocytes were retrieved during the oocyte pick up and fertilized by standard procedures of INTRACYTOPLASMIC SPERM INJECTION (ICSI). The blood samples to evaluate renal and hepatic functions were taken at the 7th day of ovarian stimulation.Results: We enrolled 426 women aged between 19 and 44 years, with a mean body mass index (BMI) of 24.68 Kg/m2. The mean value of blood urea nitrogen was 14±3.16 mg/ dl, creatinine: 1±0.45 mg/dl, uric acid: 4±1.95 mg/dl, total proteins: 7±3.93 mg/dl, aspartate aminotransferase: 18±6.29 mU/ml, alanine aminotransferase: 19±10.41 mU/ ml, alkaline phosphatase: 81±45.25 mU/ml, total bilirubin 1±0.35 mg/dL. All of the results were considered as a normal range following the Medical Council of Canada.Conclusion: Our data suggest that, unlike OVARIAN HYPERSTIMULATION syndrome (OHSS), COH patients did not show any alteration to renal and hepatic functions.

Cites

Rescue In Vitro Maturation in Polycystic Ovarian Syndrome Patients Undergoing In Vitro Fertilization Treatment who Overrespond or Underrespond to Ovarian Stimulation: Is It A Viable Option? A Case Series Study

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APA: Copy

ROMITO, ILARIA, ANTONIO GULINO, FERDINANDO, LAGANA, ANTONIO SIMONE, VITALE, SALVATORE GIOVANNI, TUSCANO, ATTILIO, LEANZA, GIANLUCA, MUSMECI, GIULIA, LEANZA, VITO, CHIARA RAPISARDA, AGNESE MARIA, & ANTONIO PALUMBO, MARCO. (2017). RENAL AND HEPATIC FUNCTIONS AFTER A WEEK OF CONTROLLED OVARIAN HYPERSTIMULATION DURING IN VITRO FERTILIZATION CYCLES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 11(1), 15-19. SID. https://sid.ir/paper/305915/en

Vancouver: Copy

ROMITO ILARIA, ANTONIO GULINO FERDINANDO, LAGANA ANTONIO SIMONE, VITALE SALVATORE GIOVANNI, TUSCANO ATTILIO, LEANZA GIANLUCA, MUSMECI GIULIA, LEANZA VITO, CHIARA RAPISARDA AGNESE MARIA, ANTONIO PALUMBO MARCO. RENAL AND HEPATIC FUNCTIONS AFTER A WEEK OF CONTROLLED OVARIAN HYPERSTIMULATION DURING IN VITRO FERTILIZATION CYCLES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2017;11(1):15-19. Available from: https://sid.ir/paper/305915/en

IEEE: Copy

ILARIA ROMITO, FERDINANDO ANTONIO GULINO, ANTONIO SIMONE LAGANA, SALVATORE GIOVANNI VITALE, ATTILIO TUSCANO, GIANLUCA LEANZA, GIULIA MUSMECI, VITO LEANZA, AGNESE MARIA CHIARA RAPISARDA, and MARCO ANTONIO PALUMBO, “RENAL AND HEPATIC FUNCTIONS AFTER A WEEK OF CONTROLLED OVARIAN HYPERSTIMULATION DURING IN VITRO FERTILIZATION CYCLES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 11, no. 1, pp. 15–19, 2017, [Online]. Available: https://sid.ir/paper/305915/en

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