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Information Journal Paper

Title

OVEREXPRESSION OF ENDOMETRIAL ESTROGEN RECEPTOR-ALPHA IN THE WINDOW OF IMPLANTATION IN WOMEN WITH UNEXPLAINED INFERTILITY

Pages

  37-42

Abstract

 Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-a) expression during IMPLANTATION may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-a in the mid-secretory phase in the endometrium of women with unexplained infertility.Materials and Methods: This case-control study was carried out on randomly selected fertile (n=10) and infertile (n=16) women whose source of infertility remained unexplained. We evaluated the expression of ER-a and GLYCODELIN-A (GdA) through mRNA level measurement with real-time polymerase chain reaction (PCR) in the endometrium of fertile women and patients suffering from unexplained infertility and fertile women. Endometrial biopsies of each subject were collected during a single menstrual cycle 7 days after the peak of luteinizing hormone (LH+7).Results: Endometrial expression level of ER-a was significantly (P<0.05) higher in the patients with unexplained infertility compared to the control. Significantly (P<0.05) lower levels of GdA expression were seen in women with unexplained infertility. A statistically non-significant negative correlation was observed between ER-a and GdA mRNA expression.Conclusion: Our findings demonstrate that reduction in the endometrial GdA expression is associated with elevated expression of ER-a in mid-luteal phase. Disruption in the endometrial ER-a expression, which leads to defects in uterine receptivity, may contribute to unexplained infertility.

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    APA: Copy

    DOROSTGHOAL, MEHRAN, GHAFFARI, HAMIDOLAH, MORAMEZI, FARIDEH, & KEIKHAH, NARJES. (2018). OVEREXPRESSION OF ENDOMETRIAL ESTROGEN RECEPTOR-ALPHA IN THE WINDOW OF IMPLANTATION IN WOMEN WITH UNEXPLAINED INFERTILITY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(1), 37-42. SID. https://sid.ir/paper/305961/en

    Vancouver: Copy

    DOROSTGHOAL MEHRAN, GHAFFARI HAMIDOLAH, MORAMEZI FARIDEH, KEIKHAH NARJES. OVEREXPRESSION OF ENDOMETRIAL ESTROGEN RECEPTOR-ALPHA IN THE WINDOW OF IMPLANTATION IN WOMEN WITH UNEXPLAINED INFERTILITY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(1):37-42. Available from: https://sid.ir/paper/305961/en

    IEEE: Copy

    MEHRAN DOROSTGHOAL, HAMIDOLAH GHAFFARI, FARIDEH MORAMEZI, and NARJES KEIKHAH, “OVEREXPRESSION OF ENDOMETRIAL ESTROGEN RECEPTOR-ALPHA IN THE WINDOW OF IMPLANTATION IN WOMEN WITH UNEXPLAINED INFERTILITY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 1, pp. 37–42, 2018, [Online]. Available: https://sid.ir/paper/305961/en

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